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100 Accelerators & Incubators
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Top 20 Accelerators and Incubators in Missouri (2026)

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Missouri's startup scene is home to a range of accelerators and incubators. They provide funding and guidance to new companies in sectors like FinTech, bioscience, and sports tech.

For example, SixThirty has made over 170 investments in its target industries. The Skandalaris Center at Washington University has also supported over 150 startups.

Below is our list of the best 20 accelerators and incubators in Missouri.

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Accelerators & Incubators List
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2,189 Accelerators & Incubators

Information about the industries, countries, and cities they generally invest in.

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Complete Unicorns List
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1,600+ Unicorns

Information about their valuation, HQ's location, founded year, name of founders, funding amount and number of employees.

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BioTech & Health Investors
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250 BioTech & Health Investors

List of startup investors in the BioTech, Health, and Medicine industries, along with their Twitter, LinkedIn, and email addresses.

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AI Investors
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250 AI Investors

List of 250 startup investors in the AI and Machine Learning industries, along with their Twitter, LinkedIn, and email addresses.

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FinTech Investors
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250 Fintech Investors

List of 250 startup investors in the FinTech and Finance industries, along with their Twitter, LinkedIn, and email addresses.

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SixThirty Logo

SixThirty fuels the growth of late seed-stage startups with capital and a hands-on accelerator program. Their expertise is concentrated on building and scaling companies in the complex worlds of FinTech, InsurTech, and Cyber Security.

Year Founded2013
FoundersBrian Matthews, Atul Kamra, Jim McKelvey
Investment Amount$100K
Equity TakenNegotiated %
Nº of Investments177
Nº of Exits32
Program TypeOn-Site
Duration (Weeks)14

Operating as the entrepreneurial heart of Washington University, the Skandalaris Center helps transform academic research and ideas into real-world businesses. They support a diverse community of students, faculty, and staff by providing the essential resources and guidance needed to launch and scale new ventures.

Year Founded2001
FoundersII Luscri
Nº of Investments151
Nº of Exits13

Stadia Ventures runs a leading accelerator for startups innovating in the sports and esports industries, connecting them with a global network of mentors and investors. Participants receive a $100K equity investment to help build and scale their ventures.

Year Founded2015
FoundersArt Chou, Tim Hayden
Investment Amount$100K equity investment per company
Nº of Investments76
Nº of Exits11
Program TypeOn-Site
Duration (Weeks)14

BioGenerator provides seed investment and hands-on venture development to launch and grow early-stage bioscience companies. They focus on startups innovating in the healthcare and agriculture sectors, providing the capital and strategic support needed to bring scientific breakthroughs to market.

Year Founded2003
FoundersTom Cohen, Matt Helms
Nº of Investments78
Nº of Exits9

Capital Innovators provides seed funding and a nationally recognized accelerator program for tech-enabled startups. They have helped launch more than 135 companies, including the publicly traded food tech company Benson Hill, by offering mentorship and strategic resources.

Year Founded2011
FoundersJudy Sindecuse
Nº of Investments138
Nº of Exits8
Duration (Weeks)13
RGAx Logo

6. RGAx

As the innovation accelerator for global reinsurance company RGA, RGAx partners with entrepreneurs and carriers to build new products and services for the life insurance industry. They provide startups with deep industry expertise and resources to transform a traditionally slow-moving sector.

Year Founded2015
Founders
Nº of Investments25
Nº of Exits5

Powered by Techstars, Sprint Accelerator is dedicated to shaping the future of mobile health by supporting early-stage companies. The program equips startups in the mobile, security, and e-commerce industries with the network and resources to bring their innovations to market.

Year Founded2012
FoundersKevin McGinnis
Nº of Investments32
Nº of Exits4
Program TypeOn-Site
Duration (Weeks)13

The Kauffman Foundation supports entrepreneurs and strengthens educational systems through grantmaking, research, and dedicated programs. Their work aims to remove barriers for new business owners and foster economic opportunity for all.

Year Founded1960
FoundersEwing Marion Kauffman
Nº of Investments111
Nº of Exits3

Digital Sandbox KC provides proof-of-concept resources to help early-stage entrepreneurs turn their innovative ideas into commercially viable products. They focus on bridging the gap between initial concept and market launch through project funding and valuable network connections.

Year Founded2003
Founders
Nº of Investments42
Nº of Exits2

As the first asset manager of its kind, WaterEquity mobilizes investment capital to address the global water and sanitation crisis. They provide financing to enterprises and microfinance institutions in emerging markets, enabling them to offer affordable loans for water and sanitation solutions to families in need.

Year Founded2017
Founders
Nº of Investments2
Nº of Exits2

10 Additional Missouri Accelerators and Incubators Worth Applying To

Beyond our favorites, many other programs are making a difference for founders. Combined, they have backed over 80 startups and guided 7 to an exit.

Each program offers something different, from industry focus to community support. Here’s a look at more startup accelerators helping founders in Missouri.

Accelerator/IncubatorYear FoundedNº InvestmentsNº Exits
Ameren Accelerator logo Ameren Accelerator2017112
Efactory logo Efactory201341
Prosper Women Entrepreneurs logo Prosper Women Entrepreneurs2014341
Think Big Partners logo Think Big Partners201041
WEPOWER logo WEPOWER2018201
1st50K logo 1st50K201521
Missouri Innovation Center logo Missouri Innovation Center19842
G.I.F.T. logo G.I.F.T.20203
Equity.com logo Equity.com20174
Sling Health logo Sling Health20131

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