Securing a Series B investment is a major step, and finding the right partner is everything. The good news is there are many active firms, from giants like Plug and Play with over 2,200 investments to established names like Index Ventures with more than 270 successful exits.
To help you cut through the noise, we've highlighted firms with a strong history of helping companies scale. These are the investors who could be a great match for your next chapter.
Below is our list of the best 75 Series B VC firms.
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Buy It For $97 $297 →Index Ventures partners with entrepreneurs to turn ambitious ideas into global businesses, supporting them from the seed stage all the way to IPO. They have backed some of the most recognizable names in modern software, including Datadog, Figma, and Notion.
| Headquarters | San Francisco, California, United States |
| Year Founded | 1996 |
| Founders | David Rimer, Giuseppe Zocco, Neil Rimer, Terrence Rohan |
| Total Funding | $12.4B |
| Average Check Size | $10M |
| Industries | AI & ML, Entertainment, Fintech, Healthcare, Media, SaaS, Productivity, Cybersecurity, Developer Tools |
| Investment Stage | Early Stage, Late Stage, Seed, Pre-Seed, Series A, Series B |
| Nº of Investments | 1246 (500 as Lead Investor) |
| Nº of Exits | 271 (53 IPO'd) |
| Top Portfolio Startups | Zendesk, Funding Circle, Datadog |
| Contact | press@indexventures.com / 415-471-1700 |
Plug and Play operates a global innovation platform that connects early-stage startups to a network of corporations and investors through its accelerator programs. This ecosystem model has helped launch major companies like Honey, Truebill, and Life360 by fostering collaboration between new ventures and established enterprises.
| Headquarters | Sunnyvale, California, United States |
| Year Founded | 2006 |
| Founders | Ali Safavi, Jackie Hernandez, Jojo Flores, Saeed Amidi |
| Total Funding | $45.5M |
| Average Check Size | $250k |
| Industries | DTC, Enterprise, Fintech, Food & Beverage, Healthcare, InsurTech, IoT, Media, Transportation, Hardware, Proptech & Real Estate, Supply Chain & Logistics, Climate & Sustainability, Travel & Hospitality, Agriculture, Energy |
| Investment Stage | Early Stage, Non Equity Assistance, Private Equity, Seed, Series A, Series B, Series C |
| Nº of Investments | 2273 (259 as Lead Investor) |
| Nº of Exits | 206 (11 IPO'd) |
| Top Portfolio Startups | Truebill, Honey, Life360 |
| Contact | press@pnptc.com / +1 408-524-1400 |
Sapphire Ventures backs global software companies from seed to late stage through its distinct direct, fund, and sport-focused investment arms. The firm helps scale companies into category leaders with a dedicated portfolio growth team and has supported well-known names like Docusign, Monday.com, and Mulesoft.
| Headquarters | Austin, Texas, United States |
| Year Founded | 1996 |
| Founders | Andreas Weiskam, David Hartwig, Doug Higgins, Jai Das, Nino Marakovic |
| Total Funding | $8.8B |
| Average Check Size | $10M |
| Industries | AI & ML, Enterprise, SaaS, Crypto & Blockchain, Cybersecurity, Big Data & Analytics, Devops, Fintech, Healthcare, Sports |
| Investment Stage | Early Stage, Late Stage, Seed, Series A, Series B |
| Nº of Investments | 368 (137 as Lead Investor) |
| Nº of Exits | 104 (33 IPO'd) |
| Top Portfolio Startups | Docusign, Monday.com, Mulesoft |
| Contact | info@sapphireventures.com / +1 650 382 1110 |
Polaris Partners invests in healthcare and biotechnology companies, supporting founders from early-stage ventures to later-stage growth. Their portfolio focuses on areas like digital health, therapeutics, and genomics, and includes companies such as Gossamer Bio and Syros Pharmaceuticals.
| Headquarters | Boston, Massachusetts, United States |
| Year Founded | 1996 |
| Founders | Jon Flint, Steve Arnold, Terrance McGuire |
| Total Funding | $4.5B |
| Average Check Size | $5M |
| Industries | Healthcare, Biotech |
| Investment Stage | Early Stage, Late Stage, Private Equity, Seed, Series A, Series B |
| Nº of Investments | 745 (215 as Lead Investor) |
| Nº of Exits | 203 (54 IPO'd) |
| Top Portfolio Startups | Gossamer Bio, Syros Pharmaceuticals, Neuronetics |
| Contact | partnership@polarispartners.com / +1 855 787 3500 |
Octopus Ventures commits over £200 million each year to companies in health, fintech, deep tech, and B2B software, supporting founders from the earliest stages through to IPO. Their model of providing deep operational support beyond just capital has helped build breakout companies like Depop, Cazoo, and Elvie.
| Headquarters | London, England, United Kingdom |
| Year Founded | 2008 |
| Founders | — |
| Total Funding | £1.2B |
| Average Check Size | £10M |
| Industries | Healthcare, Fintech, Consumer, Enterprise, SaaS, Deep Tech & Hard Science |
| Investment Stage | Debt, Early Stage, Late Stage, Seed, Series A, Series B |
| Nº of Investments | 454 (250 as Lead Investor) |
| Nº of Exits | 66 (6 IPO'd) |
| Top Portfolio Startups | Velaris, Raylo, Inflow |
| Contact | info@octopusvnetures.com / +44 20 7776 7968 |
With a portfolio that includes category-defining companies like Spotify and Klarna, Northzone partners with founders from seed to growth stages. They invest across a wide range of industries, from consumer and enterprise to fintech and healthcare, helping build enduring businesses.
| Headquarters | London, England, United Kingdom |
| Year Founded | 1996 |
| Founders | Bjorn Stray, Ingar Ostby, Karl-Christian Agerup, Tellef Thorleifsson |
| Total Funding | $1.5B |
| Average Check Size | $25M |
| Industries | Consumer, Crypto & Blockchain, Enterprise, Fintech, Gaming, Healthcare |
| Investment Stage | Early Stage, Late Stage, Seed, Series A, Series B |
| Nº of Investments | 326 (141 as Lead Investor) |
| Nº of Exits | 58 (12 IPO'd) |
| Top Portfolio Startups | Sunscreen, Pollen, Wagestream |
| Contact | +46 859905880 |
Autotech Ventures invests in startups building the future of ground transportation, targeting everything from autonomous and electric vehicles to new mobility services. They provide founders with capital and crucial access to a network of corporate transportation leaders, a model that has helped scale companies like Lyft and Volta.
| Headquarters | Menlo Park, California, United States |
| Year Founded | 2015 |
| Founders | Alexei Andreev, Dominique Houde, Quin Garcia |
| Total Funding | $30M |
| Average Check Size | $8M |
| Industries | Transportation, Deep Tech & Hard Science, AI & ML, Marketplace, Fintech, SaaS |
| Investment Stage | Early Stage, Late Stage, Seed, Series A, Series B, Series C |
| Nº of Investments | 89 (31 as Lead Investor) |
| Nº of Exits | 15 (6 IPO'd) |
| Top Portfolio Startups | Laka, Bumper, Trucklabs |
| Contact | info@autotechvc.com / (650) 515-6940 |
Playground Global provides early-stage funding to technical and scientific founders building companies in deep tech sectors like next-gen compute, automation, and engineered biology. The firm often acts as the first investor, helping to build impactful companies like PsiQuantum, Relativity Space, and MosaicML from their earliest stages.
| Headquarters | Palo Alto, California, United States |
| Year Founded | 2015 |
| Founders | Bruce Leak, Matt Hershenson, Peter Barrett, Peter Barrett |
| Industries | AI & ML, Deep Tech & Hard Science, Life Sciences, Biotech, Healthcare, Automation, Robotics, Aerospace & Space |
| Investment Stage | Early Stage, Seed, Series A, Series B |
| Nº of Investments | 128 (59 as Lead Investor) |
| Nº of Exits | 16 (1 IPO'd) |
| Contact | info@playground.global / 650-427-0000 |
As a pioneer in the space, Pantera Capital invests exclusively in companies building on blockchain technology and digital currencies like Bitcoin. They back founders from the earliest seed stages and initial coin offerings, helping to build the infrastructure for a new financial system.
| Headquarters | Menlo Park, California, United States |
| Year Founded | 2003 |
| Founders | Dan Morehead |
| Total Funding | $1.3B |
| Average Check Size | $40M |
| Industries | Crypto & Blockchain, Fintech, Consumer, Enterprise |
| Investment Stage | Early Stage, Initial Coin Offering, Late Stage, Seed, Series A, Series B |
| Nº of Investments | 294 (132 as Lead Investor) |
| Nº of Exits | 37 (16 IPO'd) |
| Top Portfolio Startups | Unstoppable Domain, Chainflip, Jambo |
| Contact | ir@panteracapital.com / +1 650 854 7000 |
With a 20-year track record, 360 Capital invests in early-stage deeptech and digital enterprises across Europe. Their portfolio features companies like Exotec, Arbe Robotics, and Sophia Genetics, reflecting a focus on sectors from robotics to AI and life sciences.
| Headquarters | Paris, Ile-de-France, France |
| Year Founded | 1997 |
| Founders | Alessandro Zaccaria, Celeste Mastria, Fausto Boni, Lucrezia L., Sebastiano Silvestri |
| Total Funding | €400M |
| Average Check Size | €2M |
| Industries | AI & ML, Robotics, Deep Tech & Hard Science, SaaS, Enterprise, Marketplace, Consumer |
| Investment Stage | Early Stage, Seed, Pre-Seed, Series A, Series B |
| Nº of Investments | 233 (78 as Lead Investor) |
| Nº of Exits | 46 (11 IPO'd) |
| Top Portfolio Startups | Alsid, Earthcube, Exotec |
| Contact | info@360cap.vc / +33 (0)1 71 18 29 12 |
65 Additional Series B VC Firms Worth Pitching
Beyond our top picks, many other great firms are funding the next generation of companies. The investors below have collectively backed over 17,000 startups and guided more than 2,500 to an exit.
While many are based in the United States, you'll find investors from Singapore to Brazil. Here’s a look at the other venture capital firms funding what's next.
