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The Full List of 53 Unicorn Startups Founded in 2021

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The year 2021 saw the creation of 53 unicorn startups across various industries. These companies range from artificial intelligence and quantum computing to biotechnology.

AI safety company Anthropic leads the cohort with an $183B valuation. Also included is Colossal Biosciences, a firm using genetic engineering for de-extinction.

Below is the full list of 53 unicorn startups that started their journey in 2021.

Top 10 Most Valuable Unicorns Founded in 2021

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Anthropic builds large-scale AI systems with a core focus on safety and making them steerable. They are best known for Claude, a family of conversational AI models designed to be helpful, harmless, and honest.

Valuation$183B (Joined February 2023)
HeadquartersSan Francisco, California, United States
Year Founded2021
FoundersDaniela Amodei, Dario Amodei, Jack Clark, Jared Kaplan, Sam McCandlish, Tom Brown
Funding Amount$33.7B
Company SizeMajor Organization (1,001-5,000)
Last Funding StatusSeries F
Top InvestorsGeneral Catalyst, Menlo Ventures, Insight Partners, General Atlantic, TPG

Helsing creates artificial intelligence software to process real-time data for defense applications. Their technology helps democratic nations protect their sovereignty by providing a critical information advantage.

Valuation$14B (Joined September 2023)
HeadquartersBerlin, Berlin, Germany
Year Founded2021
FoundersGundbert Scherf, Niklas Köhler, Torsten Reil
Funding Amount€1.4B
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries D
Top InvestorsLightspeed Venture Partners, Plural, Accel, BDT & MSD Partners, General Catalyst

Quantinuum creates some of the world's most powerful quantum computers, including their H-Series systems. Their team develops both the hardware and software to help accelerate breakthroughs in areas like chemistry, finance, and cybersecurity.

Valuation$11B
HeadquartersBroomfield, Colorado, United States
Year Founded2021
FoundersIlyas Khan
Funding Amount$925M
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries B
Top InvestorsKorea Investment Partners, NVentures, QED Investors, Amgen, JP Morgan Chase

Bilt Rewards created a loyalty program that allows renters to earn points on their monthly rent payments without transaction fees. Their platform also includes the Bilt Mastercard and a rewards network for redeeming points on travel, fitness, and future home down payments.

Valuation$11B (Joined October 2022)
HeadquartersNew York, New York, United States
Year Founded2021
FoundersAnkur Jain, David Wyler
Funding Amount$813.3M
Company SizeMid-Size Team (51-250)
Last Funding StatusVenture Round
Top InvestorsEldridge Industries, Wells Fargo, General Catalyst, Vanderbilt University, United Wholesale Mortgage

Colossal Biosciences uses breakthrough genetic engineering to bring back extinct species. They apply CRISPR gene-editing technology to resurrect lost animals and help restore damaged ecosystems.

Valuation$10B
HeadquartersAustin, Texas, United States
Year Founded2021
FoundersAndrew Busey, Ben Lamm, Brian Beard, George Church, Kent Wakeford, Peter Phillips
Funding Amount$568.1M
Company SizeMid-Size Team (51-250)
Last Funding StatusSeries C
Top InvestorsLiquid 2 Ventures, Builders VC, Capital Factory, Draper Associates, US Innovative Technology Fund

As the dedicated electric vehicle subsidiary of Tata Motors, they design and produce a growing lineup of passenger EVs. Their popular models, including the Nexon.ev and Tiago.ev, are playing a significant role in accelerating India's transition to electric mobility.

Valuation$9B
HeadquartersAndheri, Maharashtra, India
Year Founded2021
Founders
Funding Amount₹75B
Company SizeLean Team (11-50)
Last Funding StatusVenture Round
Top InvestorsTPG Rise Climate Fund

Zepto built a quick-commerce platform to deliver groceries and daily essentials to people’s doors within minutes. They operate a dense network of dark stores, enabling them to pack and send out orders at incredible speeds.

Valuation$7B (Joined August 2023)
HeadquartersParel, Maharashtra, India
Year Founded2021
FoundersAadit Palicha, Kaivalya Vohra
Funding Amount$2.6B
Company SizeEnterprise Organization (5,001+)
Last Funding StatusSeries H
Top InvestorsGeneral Catalyst, Goodwater Capital, Y Combinator, Lightspeed Venture Partners, Nexus Venture Partners

OpenEvidence builds an AI-powered platform for medical search and clinical decision support. The system is designed to synthesize vast amounts of medical literature, giving clinicians fast, evidence-based answers.

Valuation$6B (Joined February 2025)
HeadquartersCambridge, Massachusetts, United States
Year Founded2021
FoundersDaniel Nadler, Zachary Ziegler
Funding Amount$517M
Company SizeLean Team (11-50)
Last Funding StatusSeries C
Top InvestorsCoatue, Bond, Thrive Capital, Sequoia Capital, Kleiner Perkins

ClickHouse develops an open-source database system designed for real-time analytical reporting. They are known for high-performance processing that allows companies to run complex queries on massive datasets almost instantly.

Valuation$6B (Joined October 2021)
HeadquartersPalo Alto, California, United States
Year Founded2021
FoundersAaron Katz, Alexey Milovidov, Yury Izrailevsky
Funding Amount$750M
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries C
Top InvestorsInsight Partners, Bond, Bessemer Venture Partners, Peak XV Partners, Khosla Ventures

Cyera builds an AI-powered data security platform that gives enterprises deep context on their data to assure cyber-resilience and compliance. They are known for technology that automatically discovers and classifies sensitive information across a company's entire data landscape.

Valuation$6B (Joined April 2024)
HeadquartersNew York, New York, United States
Year Founded2021
FoundersTamar Bar-Ilan, Yotam Segev
Funding Amount$1.3B
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries E
Top InvestorsLightspeed Venture Partners, Cyberstarts, Spark Capital, Accel, Sequoia Capital

The Remaining 43 Unicorns Founded in 2021

The ten most valued companies are just a glimpse into the class of 2021. Beyond the biggest names, many other startups are quietly building and gaining serious traction.

A lot of this activity is happening in AI and crypto, with founders in both spaces raising significant funds. Here’s a look at the rest of the startups from 2021 that have joined the unicorn club.

Unicorn StartupMain IndustryYear FoundedAmount RaisedValuation
Changxin New Bridge logo Changxin New BridgeManufacturing2021CN¥14.6B$6B
Sierra Space logo Sierra SpaceManufacturing2021$1.7B$5B
Chainguard logo ChainguardSecurity2021$892M$4B
Fal logo FalAI2021$447M$4B
Yuga Labs logo Yuga LabsCrypto2021$450M$4B
MiniMax logo MiniMaxMedia2021$1.2B$4B
Aptos logo AptosCrypto2021$350M$4B
Phantom logo PhantomCrypto2021$268M$3B
LayerZero Labs logo LayerZero LabsMedia2021$350.8M$3B
Jasper logo JasperAI2021$131M$2B
Mysten Labs logo Mysten LabsCrypto2021$336M$2B
Berachain logo BerachainCrypto2021$142.3M$2B
Zelos logo ZelosAI2021$500M$2B
Magic Eden logo Magic EdenCrypto2021$170M$2B
Main Street Health logo Main Street HealthHealthcare2021$342M$2B
5ire logo 5ireCrypto2021$121M$2B
Scroll.io logo Scroll.ioCrypto2021$81.2M$2B
Micro Connect logo Micro ConnectFintech2021$668M$2B
ROX Motor logo ROX MotorMobility2021$1.4B$2B
Chunqing Technology logo Chunqing TechnologyMobility2021$435M$2B
Qinghai Lihao logo Qinghai LihaoHardware2021CN¥2.2B$2B
Saks.com logo Saks.comRetail2021$965M$2B
Kunlun logo KunlunAI2021$2B
XPANCEO logo XPANCEOAI2021$290M$1.35B
Raise Financial Services logo Raise Financial ServicesFintech2021$148M$1.2B
Seekr logo SeekrAI2021$164.3M$1.2B
Character.ai logo Character.aiMedia2021$150.1M$1B
Halcyon logo HalcyonAI2021$190M$1B
Nourish logo NourishMedia2021$113.1M$1B
Imbue logo ImbueAI2021$232M$1B
1Komma5° logo 1Komma5°Mobility2021€652.5M$1B
Substrate logo SubstrateHardware2021$100M$1B
Tebra logo TebraHealthcare2021$137M$1B
Modal Labs logo Modal LabsCloud2021$110.5M$1B
Silicon Box logo Silicon BoxAI2021$1.9B$1B
Andalusia Labs logo Andalusia LabsCrypto2021$51.5M$1B
GlobalBees logo GlobalBeesRetail2021$308.1M$1B
Mensa Brands logo Mensa BrandsRetail2021$293.9M$1B
Zebec logo ZebecFintech2021$42.5M$1B
Yi'an Holdings logo Yi'an HoldingsFintech2021CN¥2.1B$1B
Emplifi logo EmplifiSaaS2021$1B
Contemporary Amperex Intelligence Technology logo Contemporary Amperex Intelligence TechnologyMobility2021CN¥2B$1B
Rong Semiconductor logo Rong SemiconductorManufacturing2021$1B

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