The year 2021 saw the creation of 53 unicorn startups across various industries. These companies range from artificial intelligence and quantum computing to biotechnology.
AI safety company Anthropic leads the cohort with an $183B valuation. Also included is Colossal Biosciences, a firm using genetic engineering for de-extinction.
Below is the full list of 53 unicorn startups that started their journey in 2021.
Top 10 Most Valuable Unicorns Founded in 2021
Tool
Fundraising OS
Everything you need to raise funding for your startup, including 3,500+ investors, 7 tools, 18 templates and 3 learning resources.
Buy It For $97 $297 →Sheet
2,189 Accelerators & Incubators
Information about the industries, countries, and cities they generally invest in.
Get the Sheet for $50Sheet
1,600+ Unicorns
Information about their valuation, HQ's location, founded year, name of founders, funding amount and number of employees.
Get the Sheet for $50Sheet
250 BioTech & Health Investors
List of startup investors in the BioTech, Health, and Medicine industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50Sheet
250 AI Investors
List of 250 startup investors in the AI and Machine Learning industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50Sheet
250 Fintech Investors
List of 250 startup investors in the FinTech and Finance industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50Anthropic builds large-scale AI systems with a core focus on safety and making them steerable. They are best known for Claude, a family of conversational AI models designed to be helpful, harmless, and honest.
| Valuation | $183B (Joined February 2023) |
| Headquarters | San Francisco, California, United States |
| Year Founded | 2021 |
| Founders | Daniela Amodei, Dario Amodei, Jack Clark, Jared Kaplan, Sam McCandlish, Tom Brown |
| Funding Amount | $33.7B |
| Company Size | Major Organization (1,001-5,000) |
| Last Funding Status | Series F |
| Top Investors | General Catalyst, Menlo Ventures, Insight Partners, General Atlantic, TPG |
Helsing creates artificial intelligence software to process real-time data for defense applications. Their technology helps democratic nations protect their sovereignty by providing a critical information advantage.
| Valuation | $14B (Joined September 2023) |
| Headquarters | Berlin, Berlin, Germany |
| Year Founded | 2021 |
| Founders | Gundbert Scherf, Niklas Köhler, Torsten Reil |
| Funding Amount | €1.4B |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series D |
| Top Investors | Lightspeed Venture Partners, Plural, Accel, BDT & MSD Partners, General Catalyst |
Quantinuum creates some of the world's most powerful quantum computers, including their H-Series systems. Their team develops both the hardware and software to help accelerate breakthroughs in areas like chemistry, finance, and cybersecurity.
| Valuation | $11B |
| Headquarters | Broomfield, Colorado, United States |
| Year Founded | 2021 |
| Founders | Ilyas Khan |
| Funding Amount | $925M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series B |
| Top Investors | Korea Investment Partners, NVentures, QED Investors, Amgen, JP Morgan Chase |
Bilt Rewards created a loyalty program that allows renters to earn points on their monthly rent payments without transaction fees. Their platform also includes the Bilt Mastercard and a rewards network for redeeming points on travel, fitness, and future home down payments.
| Valuation | $11B (Joined October 2022) |
| Headquarters | New York, New York, United States |
| Year Founded | 2021 |
| Founders | Ankur Jain, David Wyler |
| Funding Amount | $813.3M |
| Company Size | Mid-Size Team (51-250) |
| Last Funding Status | Venture Round |
| Top Investors | Eldridge Industries, Wells Fargo, General Catalyst, Vanderbilt University, United Wholesale Mortgage |
Colossal Biosciences uses breakthrough genetic engineering to bring back extinct species. They apply CRISPR gene-editing technology to resurrect lost animals and help restore damaged ecosystems.
| Valuation | $10B |
| Headquarters | Austin, Texas, United States |
| Year Founded | 2021 |
| Founders | Andrew Busey, Ben Lamm, Brian Beard, George Church, Kent Wakeford, Peter Phillips |
| Funding Amount | $568.1M |
| Company Size | Mid-Size Team (51-250) |
| Last Funding Status | Series C |
| Top Investors | Liquid 2 Ventures, Builders VC, Capital Factory, Draper Associates, US Innovative Technology Fund |
As the dedicated electric vehicle subsidiary of Tata Motors, they design and produce a growing lineup of passenger EVs. Their popular models, including the Nexon.ev and Tiago.ev, are playing a significant role in accelerating India's transition to electric mobility.
| Valuation | $9B |
| Headquarters | Andheri, Maharashtra, India |
| Year Founded | 2021 |
| Founders | — |
| Funding Amount | ₹75B |
| Company Size | Lean Team (11-50) |
| Last Funding Status | Venture Round |
| Top Investors | TPG Rise Climate Fund |
Zepto built a quick-commerce platform to deliver groceries and daily essentials to people’s doors within minutes. They operate a dense network of dark stores, enabling them to pack and send out orders at incredible speeds.
| Valuation | $7B (Joined August 2023) |
| Headquarters | Parel, Maharashtra, India |
| Year Founded | 2021 |
| Founders | Aadit Palicha, Kaivalya Vohra |
| Funding Amount | $2.6B |
| Company Size | Enterprise Organization (5,001+) |
| Last Funding Status | Series H |
| Top Investors | General Catalyst, Goodwater Capital, Y Combinator, Lightspeed Venture Partners, Nexus Venture Partners |
OpenEvidence builds an AI-powered platform for medical search and clinical decision support. The system is designed to synthesize vast amounts of medical literature, giving clinicians fast, evidence-based answers.
| Valuation | $6B (Joined February 2025) |
| Headquarters | Cambridge, Massachusetts, United States |
| Year Founded | 2021 |
| Founders | Daniel Nadler, Zachary Ziegler |
| Funding Amount | $517M |
| Company Size | Lean Team (11-50) |
| Last Funding Status | Series C |
| Top Investors | Coatue, Bond, Thrive Capital, Sequoia Capital, Kleiner Perkins |
ClickHouse develops an open-source database system designed for real-time analytical reporting. They are known for high-performance processing that allows companies to run complex queries on massive datasets almost instantly.
| Valuation | $6B (Joined October 2021) |
| Headquarters | Palo Alto, California, United States |
| Year Founded | 2021 |
| Founders | Aaron Katz, Alexey Milovidov, Yury Izrailevsky |
| Funding Amount | $750M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series C |
| Top Investors | Insight Partners, Bond, Bessemer Venture Partners, Peak XV Partners, Khosla Ventures |
Cyera builds an AI-powered data security platform that gives enterprises deep context on their data to assure cyber-resilience and compliance. They are known for technology that automatically discovers and classifies sensitive information across a company's entire data landscape.
| Valuation | $6B (Joined April 2024) |
| Headquarters | New York, New York, United States |
| Year Founded | 2021 |
| Founders | Tamar Bar-Ilan, Yotam Segev |
| Funding Amount | $1.3B |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series E |
| Top Investors | Lightspeed Venture Partners, Cyberstarts, Spark Capital, Accel, Sequoia Capital |
The Remaining 43 Unicorns Founded in 2021
The ten most valued companies are just a glimpse into the class of 2021. Beyond the biggest names, many other startups are quietly building and gaining serious traction.
A lot of this activity is happening in AI and crypto, with founders in both spaces raising significant funds. Here’s a look at the rest of the startups from 2021 that have joined the unicorn club.