The biopharma sector is attracting major investment for developing new treatments. Shields Health Solutions, a specialty pharmacy accelerator, has raised $3.5 billion.
The field also includes companies like EGenesis, which is developing human compatible organs, and Cartography Biosciences, focused on cancer immunotherapies.
Below is our list of 100 Biopharma startups worth keeping an eye on.
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Get the Sheet for $50Cartography Biosciences develops cancer immunotherapies by first mapping novel and highly specific tumor antigens. This proprietary approach allows them to create targeted treatments with the potential for greater efficacy against a patient's specific cancer.
| Headquarters | San Francisco, California, United States |
| Year Founded | 2020 |
| Founders | Ansuman Satpathy, Howard Chang, Kevin Parker |
| Funding Amount | $124M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series B |
| Top Investors | Andreessen Horowitz, Gaingels, 8VC, Catalio Capital Management, Wing Venture Capital |
Shields Health Solutions partners with hospitals to build and manage on-site specialty pharmacy programs. This model helps health systems provide integrated care for patients with complex, chronic conditions and generates new revenue.
| Headquarters | Stoughton, Massachusetts, United States |
| Year Founded | 2012 |
| Founders | jack shields |
| Funding Amount | $3.5B |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Corporate Round |
| Top Investors | Evernorth |
NRG Therapeutics discovers and develops new medicines for neurodegenerative disorders like Parkinson's disease. Their work centers on creating therapeutic approaches that restore proper mitochondrial function.
| Headquarters | Cambridge, Cambridgeshire, United Kingdom |
| Year Founded | 2018 |
| Founders | Neil Miller |
| Funding Amount | $97M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series B |
| Top Investors | British Business Bank, Brandon Capital, Omega Funds, Dementia Discovery Fund, Michael J. Fox Foundation |
Sparrow Pharmaceuticals develops targeted therapies for disorders related to corticosteroid excess. The clinical-stage biopharmaceutical company is advancing a lead product candidate to treat conditions such as Cushing's syndrome.
| Headquarters | Portland, Oregon, United States |
| Year Founded | 2013 |
| Founders | David Katz |
| Funding Amount | $156.3M |
| Startup Size | Founding Team (1-10) |
| Last Funding Status | Series B |
| Top Investors | OrbiMed, RA Capital Management, U.S. Venture Partners, RiverVest, Forbion Capital Partners |
Salt AI builds a visual development platform for creating enterprise applications in the life sciences and health tech industries. Their contextual AI technology helps teams develop complex solutions without needing deep coding expertise.
| Headquarters | Los Angeles, California, United States |
| Year Founded | 2023 |
| Founders | Aber Whitcomb, Jim Benedetto |
| Funding Amount | $13M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Seed |
| Top Investors | CoreWeave, Struck Capital, Irregular Expressions, Morpheus Ventures, Marbruck |
EGenesis uses gene editing technology to develop human-compatible organs for transplantation. The company's work in genome engineering aims to address the global organ shortage and provide new treatments for end-stage organ failure.
| Headquarters | Cambridge, Massachusetts, United States |
| Year Founded | 2014 |
| Founders | Geoff MacKay, George Church, Luhan Yang |
| Funding Amount | $456M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series D |
| Top Investors | Khosla Ventures, Lux Capital, ARCH Venture Partners, Catalio Capital Management, Alta Partners |
Enlaza Therapeutics is pioneering the field of covalent biologics to create a new class of drugs for treating cancer. Their proprietary War-Lock™ platform engineers highly specific protein drugs with improved therapeutic properties.
| Headquarters | La Jolla, California, United States |
| Year Founded | 2020 |
| Founders | Sanford J. Madigan, Sergio Duron |
| Funding Amount | $180M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Venture Round |
| Top Investors | Lightspeed Venture Partners, Frazier Life Sciences, Samsara BioCapital, Regeneron, J.P. Morgan Asset Management |
AusperBio develops innovative drugs with the goal of curing chronic hepatitis B. Their work in biotechnology also extends to creating treatments for other major infectious diseases.
| Headquarters | Foster City, California, United States |
| Year Founded | 2019 |
| Founders | Chris Yang, Guofeng Cheng |
| Funding Amount | $237M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series B |
| Top Investors | Qiming Venture Partners, CDH Investments, BioVenture, Genesis Capital, Sherpa Healthcare Partners |
Retro Biosciences develops therapies to combat diseases driven by the aging process. The company's research pursues three distinct approaches, cellular reprogramming, autophagy, and plasma-inspired therapeutics, to achieve its mission of extending healthy human lifespan.
| Headquarters | Redwood City, California, United States |
| Year Founded | 2021 |
| Founders | Joe Betts-Lacroix |
| Funding Amount | $180M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Angel |
| Top Investors | Sam Altman |
Opus Genetics develops gene therapies to treat rare inherited retinal diseases. Their work focuses on creating treatments for conditions that currently have limited or no options, potentially restoring vision for patients.
| Headquarters | Raleigh, North Carolina, United States |
| Year Founded | 2004 |
| Founders | Jason D. Menzo, Jean Bennett, Peter Ginsberg, Rusty Kelley |
| Funding Amount | $22.7M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Grant |
| Top Investors | Foundation Fighting Blindness, Bios Partners, Retinal Degeneration Fund, Manning Family Foundation |
90 Additional Biopharma Startups Worth Following
Our top 10 picks are just a small slice of the activity happening in the biopharma space. Altogether, these companies have raised billions of dollars to push science forward.
You'll find a mix of brand new ventures and more established names, with many using AI to discover new medicines. Here’s a look at the other startups shaping the industry.