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Top 100 Biopharma Startups to Watch in 2026

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The biopharma sector is attracting major investment for developing new treatments. Shields Health Solutions, a specialty pharmacy accelerator, has raised $3.5 billion.

The field also includes companies like EGenesis, which is developing human compatible organs, and Cartography Biosciences, focused on cancer immunotherapies.

Below is our list of 100 Biopharma startups worth keeping an eye on.

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Cartography Biosciences develops cancer immunotherapies by first mapping novel and highly specific tumor antigens. This proprietary approach allows them to create targeted treatments with the potential for greater efficacy against a patient's specific cancer.

HeadquartersSan Francisco, California, United States
Year Founded2020
FoundersAnsuman Satpathy, Howard Chang, Kevin Parker
Funding Amount$124M
Startup SizeLean Team (11-50)
Last Funding StatusSeries B
Top InvestorsAndreessen Horowitz, Gaingels, 8VC, Catalio Capital Management, Wing Venture Capital

Shields Health Solutions partners with hospitals to build and manage on-site specialty pharmacy programs. This model helps health systems provide integrated care for patients with complex, chronic conditions and generates new revenue.

HeadquartersStoughton, Massachusetts, United States
Year Founded2012
Foundersjack shields
Funding Amount$3.5B
Startup SizeLarge Team (251-1,000)
Last Funding StatusCorporate Round
Top InvestorsEvernorth

NRG Therapeutics discovers and develops new medicines for neurodegenerative disorders like Parkinson's disease. Their work centers on creating therapeutic approaches that restore proper mitochondrial function.

HeadquartersCambridge, Cambridgeshire, United Kingdom
Year Founded2018
FoundersNeil Miller
Funding Amount$97M
Startup SizeLean Team (11-50)
Last Funding StatusSeries B
Top InvestorsBritish Business Bank, Brandon Capital, Omega Funds, Dementia Discovery Fund, Michael J. Fox Foundation

Sparrow Pharmaceuticals develops targeted therapies for disorders related to corticosteroid excess. The clinical-stage biopharmaceutical company is advancing a lead product candidate to treat conditions such as Cushing's syndrome.

HeadquartersPortland, Oregon, United States
Year Founded2013
FoundersDavid Katz
Funding Amount$156.3M
Startup SizeFounding Team (1-10)
Last Funding StatusSeries B
Top InvestorsOrbiMed, RA Capital Management, U.S. Venture Partners, RiverVest, Forbion Capital Partners

Salt AI builds a visual development platform for creating enterprise applications in the life sciences and health tech industries. Their contextual AI technology helps teams develop complex solutions without needing deep coding expertise.

HeadquartersLos Angeles, California, United States
Year Founded2023
FoundersAber Whitcomb, Jim Benedetto
Funding Amount$13M
Startup SizeLean Team (11-50)
Last Funding StatusSeed
Top InvestorsCoreWeave, Struck Capital, Irregular Expressions, Morpheus Ventures, Marbruck

EGenesis uses gene editing technology to develop human-compatible organs for transplantation. The company's work in genome engineering aims to address the global organ shortage and provide new treatments for end-stage organ failure.

HeadquartersCambridge, Massachusetts, United States
Year Founded2014
FoundersGeoff MacKay, George Church, Luhan Yang
Funding Amount$456M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries D
Top InvestorsKhosla Ventures, Lux Capital, ARCH Venture Partners, Catalio Capital Management, Alta Partners

Enlaza Therapeutics is pioneering the field of covalent biologics to create a new class of drugs for treating cancer. Their proprietary War-Lock™ platform engineers highly specific protein drugs with improved therapeutic properties.

HeadquartersLa Jolla, California, United States
Year Founded2020
FoundersSanford J. Madigan, Sergio Duron
Funding Amount$180M
Startup SizeMid-Size Team (51-250)
Last Funding StatusVenture Round
Top InvestorsLightspeed Venture Partners, Frazier Life Sciences, Samsara BioCapital, Regeneron, J.P. Morgan Asset Management

AusperBio develops innovative drugs with the goal of curing chronic hepatitis B. Their work in biotechnology also extends to creating treatments for other major infectious diseases.

HeadquartersFoster City, California, United States
Year Founded2019
FoundersChris Yang, Guofeng Cheng
Funding Amount$237M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries B
Top InvestorsQiming Venture Partners, CDH Investments, BioVenture, Genesis Capital, Sherpa Healthcare Partners

Retro Biosciences develops therapies to combat diseases driven by the aging process. The company's research pursues three distinct approaches, cellular reprogramming, autophagy, and plasma-inspired therapeutics, to achieve its mission of extending healthy human lifespan.

HeadquartersRedwood City, California, United States
Year Founded2021
FoundersJoe Betts-Lacroix
Funding Amount$180M
Startup SizeMid-Size Team (51-250)
Last Funding StatusAngel
Top InvestorsSam Altman

Opus Genetics develops gene therapies to treat rare inherited retinal diseases. Their work focuses on creating treatments for conditions that currently have limited or no options, potentially restoring vision for patients.

HeadquartersRaleigh, North Carolina, United States
Year Founded2004
FoundersJason D. Menzo, Jean Bennett, Peter Ginsberg, Rusty Kelley
Funding Amount$22.7M
Startup SizeLean Team (11-50)
Last Funding StatusGrant
Top InvestorsFoundation Fighting Blindness, Bios Partners, Retinal Degeneration Fund, Manning Family Foundation

90 Additional Biopharma Startups Worth Following

Our top 10 picks are just a small slice of the activity happening in the biopharma space. Altogether, these companies have raised billions of dollars to push science forward.

You'll find a mix of brand new ventures and more established names, with many using AI to discover new medicines. Here’s a look at the other startups shaping the industry.

StartupMain IndustryYear FoundedAmount RaisedLast Funding Round
MapLight Therapeutics logo MapLight TherapeuticsBiotech2018$640.6MSeries D
Full-Life Technologies logo Full-Life TechnologiesBiotech2021$187.3MSeries C
EnsiliTech logo EnsiliTechBiotech2022£8.8MSeed
Genoskin logo GenoskinBiotech2011$8.7MSeries A
Altos Labs logo Altos LabsBiotech2021$3BSeries A
Resilience logo ResilienceBiotech2020$2.5BGrant
Interius BioTherapeutics logo Interius BioTherapeuticsBiotech2019$175.9MUndisclosed
Gameto logo GametoBiotech2020$117MSeries C
Healx logo HealxAI2014$114.9MVenture Round
Umoja Biopharma logo Umoja BiopharmaBiotech2019$363MSeries C
Prellis Biologics logo Prellis BiologicsManufacturing2016$79.4MSeries C
ADvantage Therapeutics logo ADvantage TherapeuticsBiotech2021$21.2MGrant
Manus Bio logo Manus BioBiotech2011$131.1MGrant
OncoC4 logo OncoC4Biotech2020$50MSeries B
Ryght AI logo Ryght AIAI2023$5.5MSeed
Avalyn Pharma logo Avalyn PharmaBiotech2011$372.5MSeries D
Juvena Therapeutics logo Juvena TherapeuticsBiotech2017$79.7MVenture Round
Terray Therapeutics logo Terray TherapeuticsAI2018$200MSeries B
Crystalys Therapeutics logo Crystalys TherapeuticsBiotech2025$205MSeries A
Asklepios BioPharmaceutical logo Asklepios BioPharmaceuticalBiotech2001$241.8MGrant
Highlight Therapeutics logo Highlight TherapeuticsBiotech2010$37.6MVenture Round
Datavant logo DatavantBiotech2017$80.5MSeries B
3T Biosciences logo 3T BiosciencesBiotech2017$52MSeries A
Jocasta Neuroscience logo Jocasta NeuroscienceBiotech2021$66.6MSeries A
Caristo Diagnostics logo Caristo DiagnosticsBiotech2018$30.1MVenture Round
Aera Therapeutics logo Aera TherapeuticsBiotech2021$193MSeries B
Kardigan logo KardiganBiotech2023$300MSeries A
LatchBio logo LatchBioAI2021$33.2MSeries A
Paige logo PaigeBiotech2018$220MSeries C
Arbor Biotechnologies logo Arbor BiotechnologiesBiotech2016$304.5MSeries C
BPGbio logo BPGbioBiotech2006$480MPrivate Equity
YolTech Therapeutics logo YolTech TherapeuticsBiotech2021CN¥500MSeries B
Arnatar Therapeutics logo Arnatar TherapeuticsBiotech2022$66.3MSeries A
Olatec Therapeutics logo Olatec TherapeuticsBiotech2003$102.3MGrant
64x Bio logo 64x BioBiotech2017$59.5MSeries A
ResBiotic logo ResBioticBiotech2018$16.1MSeries A
BioSapien logo BioSapienBiotech2018$45.1MSeed
BlossomHill Therapeutics logo BlossomHill TherapeuticsBiotech2020$173MSeries B
Resolution Therapeutics logo Resolution TherapeuticsBiotech2017£60MSeries B
BrightInsight logo BrightInsightBiotech2017$166MSeries C
Anocca logo AnoccaBiotech2014$156.5MVenture Round
VelaVigo logo VelaVigoBiotech2021$160MSeed
Numab logo NumabBiotech2011CHF172MSeries C
Juvenescence logo JuvenescenceBiotech2016$295.2MSeries B
BlueRock Therapeutics logo BlueRock TherapeuticsBiotech2016$225MSeries A
21st.BIO logo 21st.BIOBiotech2020$86MVenture Round
Tafalgie Therapeutics logo Tafalgie TherapeuticsBiotech2020$12MSeries A
Mabwell Biotech logo Mabwell BiotechBiotech2017$278.5MSeries A
Verdant Impact logo Verdant ImpactAgTech2020$316.2kSeed
LIfT BioSciences logo LIfT BioSciencesBiotech2016$38.4MGrant
Artios Pharma logo Artios PharmaBiotech2016$298.3MSeries C
CN Bio logo CN BioBiotech2009$44.5MSeries B
Veminsyn logo VeminsynBiotech2021CN¥199MSeries B
AnaCardio logo AnaCardioBiotech2017SEK388MSeries A
Swixx Biopharma logo Swixx BiopharmaBiotech2014$102MVenture Round
SOMAÍ logo SOMAÍBiotech2019$38.2MSeries C
Affinity logo AffinityBiotech2011CN¥700MSeries B
Angelini Pharma logo Angelini PharmaBiotech1919€1.5MGrant
Angitia Biopharmaceuticals logo Angitia BiopharmaceuticalsBiotech2018$276MSeries C
TreeFrog Therapeutics logo TreeFrog TherapeuticsBiotech2018$121.1MDebt Financing
ImCheck Therapeutics logo ImCheck TherapeuticsBiotech2015€193.1MGrant
Augustine Therapeutics logo Augustine TherapeuticsBiotech2019€98.9MSeries A
Arctic Therapeutics logo Arctic TherapeuticsBiotech2015€39MSeries A
Octarine Bio logo Octarine BioBiotech2018$9.7MSeries A
Neurosterix logo NeurosterixBiotech2024€63MSeries A
ENYO Pharma logo ENYO PharmaBiotech2014€96.5MSeries C
Muna Therapeutics logo Muna TherapeuticsBiotech2020$77.9MGrant
bYoRNA logo bYoRNABiotech2022€1.5MPre-Seed
METiS Pharmaceuticals logo METiS PharmaceuticalsAI2020$391.7MSeries D
E-nitiate Biopharmaceuticals logo E-nitiate BiopharmaceuticalsBiotech2020$45.6MSeries B
Biomatter logo BiomatterBiotech2018€7MSeed
Eleva logo ElevaBiotech1999€60MVenture Round
ABclonal logo ABclonalSecurity2011$282.1MSeries D
VECT-HORUS logo VECT-HORUSBiotech2005€18MSeries D
Chime Biologics logo Chime BiologicsBiotech2013$332.4MSeries A
XuanZhu Pharma logo XuanZhu PharmaBiotech2002CN¥1.6BSeries B
Nintx logo NintxBiotech2021$15MSeries A
Caremo logo CaremoBiotech2020CN¥150MSeries B
Creative Biosciences logo Creative BiosciencesBiotech2015$230.9MSeries D
XellSmart logo XellSmartBiotech2021CN¥177MSeries B
Haichang Biotech logo Haichang BiotechBiotech2013CN¥500MSeries C
KyDo Therapeutics logo KyDo TherapeuticsBiotech2024€4.5MSeed
Vivasure Medical logo Vivasure MedicalBiotech2008$98.9MSeries D
Cytomos logo CytomosBiotech2011£10.7MVenture Round
Turbine logo TurbineAI2015€34.2MVenture Round
CoJourney logo CoJourneyBiotech2022$30MSeries A
Tianchen Biotechnology logo Tianchen BiotechnologyBiotech2018CN¥300MSeries C
Trioar logo TrioarBiotech2021₩22.8BSeries B
Axcynsis Therapeutics logo Axcynsis TherapeuticsBiotech2021$15MSeed
Baoling Bio logo Baoling BioBiotech2019CN¥486.3MSeries B

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