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Top 35 Maryland Startups to Watch in 2026

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Maryland's startup ecosystem shows significant strength in sectors like clean energy, defense technology, and cybersecurity. These companies are spread throughout the state, from Rockville to Baltimore.

Clean energy developer X-energy leads with $1B in total funding. Other major players include autonomous systems firm Forterra and cybersecurity company Huntress, which have raised $411.3M and $309.8M respectively.

Below is our list of 35 Maryland startups worth keeping an eye on.

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X-energy develops advanced small modular nuclear reactors and proprietary fuel to provide clean, reliable energy. Their technology is designed to be a safer and more scalable alternative to traditional nuclear power plants.

Year Founded2009
FoundersKam Ghaffarian
Funding Amount$1B
Startup SizeLarge Team (251-1,000)
Last Funding StatusPrivate Equity
Top InvestorsAlumni Ventures, Ares Management, Jane Street Capital, University of Michigan, NGP Energy Capital Management

Forterra develops autonomous systems for ground-based vehicles, focusing on defense and industrial applications. Their AutoDrive® platform is a vehicle-agnostic software kit that can be retrofitted onto existing vehicles for complex, off-road operations.

Year Founded2002
FoundersAlberto Lacaze, Karl Murphy
Funding Amount$411.3M
Startup SizeLarge Team (251-1,000)
Last Funding StatusUndisclosed
Top InvestorsXYZ Venture Capital, Luminar, SoftBank Vision Fund, Crescent Cove Advisors, Enlightenment Capital

Mytonomy builds healthcare cloud solutions focused on video-based patient education and engagement. Their platform enables providers to stream tailored video content, helping patients better understand their medical journey and treatment options.

Year Founded2011
FoundersAnjali Kataria, Vinay Bhargava
Funding Amount$32M
Startup SizeLean Team (11-50)
Last Funding Status
Top InvestorsLevel Equity Management, Kapor Capital, NewSchools Venture Fund, MedStar Health, Gokul Rajaram

Huntress builds a managed security platform that combines automated detection software with a team of human threat analysts. They focus on delivering enterprise-grade cybersecurity to small and mid-sized businesses, a market often underserved by other security providers.

Year Founded2015
FoundersChris Bisnett, John Ferrell, Kyle Hanslovan, Liz Kokoska
Funding Amount$309.8M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries D
Top InvestorsSapphire Ventures, JMI Equity, Kleiner Perkins, Forgepoint Capital, SaaS Ventures

Employee Navigator builds an all-in-one software platform for benefits, HR, and compliance. Their SaaS solution is designed for insurance brokers and HR departments to manage everything from new hire onboarding to ACA reporting.

Year Founded2008
FoundersGeorge Reese
Funding Amount$134M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSecondary Market
Top InvestorsJMI Equity, Spectrum Equity

EcoMap Technologies creates AI-driven platforms that map and organize complex ecosystems such as industries and communities. Their technology makes information accessible by automatically centralizing resources and data into a single, navigable platform.

Year Founded2018
FoundersAnthony Caesar, Pava LaPere, Sherrod Davis
Funding Amount$14.3M
Startup SizeLean Team (11-50)
Last Funding StatusUndisclosed
Top InvestorsTEDCO, Techstars, Las Olas Venture Capital, Cofounders Capital, Conscious Venture Lab

b.well Connected Health offers a digital health platform that unifies a person's complete medical history in one place. The technology aggregates records from various sources, including doctors, labs, and insurance plans, to give individuals a comprehensive view of their health data.

Year Founded2015
FoundersBryan Jones, Kristen Valdes
Funding Amount$118.8M
Startup SizeMid-Size Team (51-250)
Last Funding StatusDebt Financing
Top InvestorsTrinity Capital, Portfolia, Capital Factory, RTI International, Keiretsu Capital

Quantum Xchange builds a crypto-agile key delivery system that makes an organization's transmitted data safe from quantum computing attacks. The company's Phio Trusted Xchange (TX) platform is designed to protect against "harvest now, decrypt later" threats by future-proofing existing encryption.

Year Founded2018
FoundersHal Chapel
Funding Amount$23.5M
Startup SizeFounding Team (1-10)
Last Funding StatusSeries A
Top InvestorsNew Technology Ventures

Scene Health tackles medication non-adherence through a program that combines personalized support with video technology. Their platform uses a method called video Directly Observed Therapy (DOT), helping patients with chronic and infectious diseases stick to their treatment plans.

Year Founded2008
FoundersMorad Elmi, Sebastian Seiguer, Sharon Kong
Funding Amount$36.4M
Startup SizeMid-Size Team (51-250)
Last Funding StatusGrant
Top InvestorsGaingels, TEDCO, Kapor Capital, National Institutes of Health, Sand Hill Angels

InventWood creates a new class of advanced materials by transforming natural wood for high-performance applications. The company's portfolio includes products like MettleWood, a material stronger than steel, designed as a sustainable alternative for the manufacturing and construction industries.

Year Founded2016
FoundersAmy Gong
Funding Amount$44M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top InvestorsMaryland Department of Commerce, US Department of Energy, Builders Vision, MUUS Climate Partners, Grantham Foundation

25 Additional Maryland Startups Worth Following

Those top ten companies are just a small slice of what’s happening in Maryland right now. The state has a deep bench of startups in biotech and security, which together have raised more than $1.8 billion.

Some are just getting started while others have been growing for years. Here are the other companies that make Maryland's startup community so strong.

StartupIndustryYear FoundedAmount RaisedLast Funding Round
Noxilizer logo NoxilizerBiotech2004$34.4MPrivate Equity
Blend360 logo Blend360Analytics2016$100MPrivate Equity
OncoC4 logo OncoC4Biotech2020$50MSeries B
Viamericas logo ViamericasFintech1999$119.6MDebt Financing
DrFirst logo DrFirstHealthcare2000$202.6MVenture Round
Impact Analytics logo Impact AnalyticsAnalytics2015$76.7MSeries D
Aembit logo AembitSecurity2021$43MSeries A
NZXT logo NZXTHardware2004$103.1MVenture Round
Rapafusyn Pharmaceuticals logo Rapafusyn PharmaceuticalsBiotech2015$44MSeries A
Polaris Genomics logo Polaris GenomicsBiotech2017$5.6MDebt Financing
Blackpoint Cyber logo Blackpoint CyberHardware2014$201.4MSeries C
Netography logo NetographySecurity2018$47.6MSeries A
RoosterBio logo RoosterBioBiotech2012$41MGrant
Xona Systems logo Xona SystemsSecurity2017$27.2MVenture Round
PediaMetrix logo PediaMetrixAI2018$6.5MGrant
LePrix logo LePrixEnterprise2014$5.9MVenture Round
Cardinality.ai logo Cardinality.aiAI2017$12.5MSeries B
SixMap logo SixMapSecurity2020$18.8MVenture Round
Haystack Oncology logo Haystack OncologyBiotech2021$56MSeries A
AbsoluteCARE logo AbsoluteCAREHealthcare2000$252MPrivate Equity
Royal Farms logo Royal FarmsFood1959$1.8MGrant
Qu logo QuTravel2012$12.9MVenture Round
Keep Company logo Keep CompanyEnterprise2022$2.7MSeed
Precision Medicine Group logo Precision Medicine GroupBiotech2012$310.2MVenture Round
WealthEngine logo WealthEngineAnalytics1991$22.2MDebt Financing

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