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Top 9 Pittsburgh Startups to Watch in 2026

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Pittsburgh's startup scene shows a strong focus on artificial intelligence and healthcare, attracting significant investment. The city is home to a diverse group of companies, from recently founded ventures to more established players.

For example, Abridge, a healthcare AI company, has secured $757.5 million in funding. Another AI startup, Skild AI, has raised $435 million to develop software for robots.

Below is our list of 9 Pittsburgh startups worth keeping an eye on.

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Skild AI is building foundational software that allows robots to learn and execute complex physical tasks. Their general-purpose AI model is designed to power a wide variety of robotic hardware and make automation more adaptable.

Year Founded2023
FoundersAbhinav Gupta Abhinav Gupta, Deepak Pathak
Funding Amount$435M
Startup SizeLean Team (11-50)
Last Funding StatusSeries B
Top InvestorsMenlo Ventures, General Catalyst, NVIDIA, Lightspeed Venture Partners, Sequoia Capital

Abridge builds an AI platform that transforms patient-clinician conversations into structured clinical notes. Their technology is designed to automate documentation, helping to reduce physician burnout and improve the quality of patient care.

Year Founded2018
FoundersFlorian Metze, Sandeep Konam, Shivdev Rao
Funding Amount$757.5M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries E
Top InvestorsAndreessen Horowitz, Khosla Ventures, Lightspeed Venture Partners, Bessemer Venture Partners, IVP

Pointsville has developed a platform that allows businesses to create and manage their own digital assets and loyalty programs. Their software aims to simplify the process of launching these initiatives, helping companies drive customer engagement and innovation.

Year Founded2020
FoundersGabor Gurbacs
Funding Amount$10M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top InvestorsChainlink Labs, Tether, Dynamo, Valor Capital Group, Itau Unibanco

Niche.com has built a platform for researching and discovering U.S. colleges, schools, and neighborhoods. The site combines user reviews with extensive data to offer detailed profiles and rankings, helping people make major life decisions.

Year Founded2002
FoundersChristina Koshzow, Joey Rahimi, Luke Skurman
Funding Amount$44.3M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries C
Top InvestorsSalesforce Ventures, Radian Capital, Allen & Company, Graph Ventures, Grit Capital Partners

Carnegie Learning develops innovative math programs for students in middle school, high school, and post-secondary education. Their research-backed curricula combine print and digital resources to help learners master complex mathematical concepts.

Year Founded1997
FoundersKenneth R. Koedinger, Steve Ritter
Funding Amount$23.9M
Startup SizeLarge Team (251-1,000)
Last Funding StatusGrant
Top InvestorsCarnegie Mellon University, Madison Dearborn Partners, NewSchools Venture Fund, CIP Capital, U.S. Department of Education

CytoAgents develops pharmaceutical products to treat cytokine release syndrome, a life-threatening inflammatory response triggered by viral infections. They are creating a lead drug candidate to safely manage the body's reaction to diseases like influenza and COVID-19.

Year Founded2018
FoundersTeresa Whalen
Funding Amount$21.5M
Startup SizeFounding Team (1-10)
Last Funding StatusGrant
Top InvestorsInnovation Works, National Institutes of Health, Richard King Mellon Foundation, AlphaLab Health, EQx Fund

Efficient Computer is creating a general-purpose processor engineered for world-class energy efficiency. Their hardware is designed to power demanding computational tasks, particularly in AI, while dramatically reducing electricity consumption.

Year Founded2022
FoundersAlex Hawkinson, Brandon Lucia, Graham Gobieski, Nathan Beckmann
Funding Amount$16M
Startup SizeLean Team (11-50)
Last Funding StatusSeed
Top InvestorsEclipse Ventures

BlastPoint builds a customer intelligence platform that uses AI to help businesses better understand their customers. The software provides analytics and data integration to identify high-value segments and drive revenue growth.

Year Founded2016
FoundersAlison Alvarez, Derek Gregg, Tomer Borenstein
Funding Amount$6.2M
Startup SizeLean Team (11-50)
Last Funding StatusSeed
Top InvestorsAlumni Ventures, Carnegie Mellon University, Cardumen Capital, Innovation Works, Allos Ventures

Surface Design Solutions works with manufacturers to develop customized surface metrics through machine learning. Their technology analyzes surface data to identify key features, helping companies improve product quality and process control.

Year Founded
Founders
Funding Amount$465k
Startup SizeFounding Team (1-10)
Last Funding StatusGrant
Top InvestorsAI Horizons, Richard King Mellon Foundation

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