The machine learning landscape is defined by significant capital investment and a recent surge of new companies. This activity is largely focused on generative AI and geographically centered in California.
Established players like OpenAI have raised $78 billion, while younger companies like Anthropic and xAI are also securing tens of billions in capital. The following companies represent the key drivers in this space.
Below is our list of 100 Machine Learning startups worth keeping an eye on.
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Get the Sheet for $50Anthropic develops large-scale AI models with a core focus on safety and aligning them with human values. Their primary product is Claude, a family of AI assistants designed to be helpful, harmless, and honest.
| Headquarters | San Francisco, California, United States |
| Year Founded | 2021 |
| Founders | Daniela Amodei, Dario Amodei, Jack Clark, Jared Kaplan, Sam McCandlish, Tom Brown |
| Funding Amount | $33.7B |
| Startup Size | Major Organization (1,001-5,000) |
| Last Funding Status | Series F |
| Top Investors | Menlo Ventures, TPG, General Catalyst, BlackRock, Insight Partners |
Perplexity created an AI answer engine to provide direct, accurate responses to complex questions. The platform combines search with a conversational AI to deliver real-time information complete with source citations.
| Headquarters | San Francisco, California, United States |
| Year Founded | 2022 |
| Founders | Andy Konwinski, Aravind Srinivas, Denis Yarats, Johnny Ho |
| Funding Amount | $1.5B |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Venture Round |
| Top Investors | NVIDIA, Accel, Bessemer Venture Partners, New Enterprise Associates, IVP |
xAI develops artificial intelligence with the stated mission of understanding the true nature of the universe. Its first model, Grok, is a conversational AI designed to answer questions with real-time information from the 𝕏 platform.
| Headquarters | Burlingame, California, United States |
| Year Founded | 2023 |
| Founders | Christian Szegedy, Elon Musk, Greg Yang, Igor Babuschkin, Kyle Kosic, Manuel Kroiss, Toby Pohlen, Yuhuai Wu |
| Funding Amount | $22.7B |
| Startup Size | Major Organization (1,001-5,000) |
| Last Funding Status | Corporate Round |
| Top Investors | Andreessen Horowitz, NVIDIA, Tribe Capital, BlackRock, Sequoia Capital |
OpenAI develops advanced artificial intelligence models as a leading AI research and deployment company. They are best known for creating ChatGPT, a powerful conversational AI that has achieved widespread popularity.
| Headquarters | San Francisco, California, United States |
| Year Founded | 2015 |
| Founders | Andrej Karpathy, Durk Kingma, Elon Musk, Greg Brockman, Ilya Sutskever, John Schulman, Pamela Vagata, Sam Altman, Trevor Blackwell, Vicki Cheung, Wojciech Zaremba |
| Funding Amount | $78B |
| Startup Size | Major Organization (1,001-5,000) |
| Last Funding Status | Venture Round |
| Top Investors | Andreessen Horowitz, TPG, NVIDIA, Citi, Khosla Ventures |
Mistral AI develops a range of powerful large language models, with a focus on open-source and commercially available options for enterprises. Their platform offers tailored AI services that allow businesses to deploy and customize generative AI for their specific applications.
| Headquarters | Paris, Ile-de-France, France |
| Year Founded | 2023 |
| Founders | Arthur Mensch, Charles Gorintin, Guillaume Lample, Jean Charles Samuelian, Timothee Lacroix |
| Funding Amount | €2.8B |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Series C |
| Top Investors | Andreessen Horowitz, General Catalyst, NVIDIA, Bpifrance, Lightspeed Venture Partners |
Glean builds an AI-powered search platform for the enterprise that connects all of a company's apps and data. This unified system allows employees to find information instantly and get AI-generated answers to their questions, improving workplace efficiency.
| Headquarters | Palo Alto, California, United States |
| Year Founded | 2019 |
| Founders | Arvind Jain, Piyush Prahladka, Prafful Goel, Sharvanath Pathak, Tony Gentilcore, TR Vishwanath |
| Funding Amount | $768.2M |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Series F |
| Top Investors | General Catalyst, Wellington Management, Citi, Khosla Ventures, Lightspeed Venture Partners |
EliseAI develops an AI-powered platform to automate conversations and streamline workflows for the real estate industry. Their technology handles tasks like scheduling tours and answering resident questions, freeing up property management teams to focus on higher-value work.
| Headquarters | New York, New York, United States |
| Year Founded | 2017 |
| Founders | Minna Song, Stoyan Stoyanov |
| Funding Amount | $391.9M |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Series E |
| Top Investors | Andreessen Horowitz, Bessemer Venture Partners, Sapphire Ventures, Golden Seeds, Navitas Capital |
As an applied research lab, Anysphere builds AI solutions like Cursor to automate the process of writing code. These developer tools are designed to help software engineers streamline their workflows and build products more efficiently.
| Headquarters | San Francisco, California, United States |
| Year Founded | 2022 |
| Founders | Aman Sanger, Arvid Lunnemark, Michael Truell, Sualeh Asif |
| Funding Amount | $3.4B |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series D |
| Top Investors | Andreessen Horowitz, Accel, Google, NVIDIA, Benchmark, Thrive Capital, DST Global |
Databricks builds a unified data and AI platform for data engineering, analytics, and machine learning. They pioneered the lakehouse architecture, which combines the reliability of data warehouses with the scale of data lakes.
| Headquarters | San Francisco, California, United States |
| Year Founded | 2013 |
| Founders | Ali Ghodsi, Andy Konwinski, Arsalan Tavakoli-Shiraji, Ion Stoica, Matei Zaharia, Patrick Wendell, Reynold Xin |
| Funding Amount | $21.8B |
| Startup Size | Enterprise Organization (5,001+) |
| Last Funding Status | Venture Round |
| Top Investors | Franklin Templeton, Andreessen Horowitz, NVIDIA, Temasek Holdings, Gaingels |
Labs develops a human-enhancement platform using AI and augmented reality to merge digital interactions with physical spaces. Their operating system, LAV® OS, provides a unified digital identity for users to navigate these interconnected virtual and real-world environments.
| Headquarters | Santa Monica, California, United States |
| Year Founded | 2025 |
| Founders | Duránd F. Davis Jr., Maya Elz Davis |
| Funding Amount | $65M |
| Startup Size | Founding Team (1-10) |
| Last Funding Status | Debt Financing |
| Top Investors | JetDebt Finance, Jet Investments Group, Davis&Davis Venture Partners, JET Venture Capital, JET VC-IRA FUND |
90 Additional Machine Learning Startups Worth Following
Our top picks offer just a glimpse into the machine learning space. Together, the companies on our full list have raised tens of billions of dollars to build new products across dozens of industries.
You'll find a mix of brand new startups and more established players, with most of them focused on AI and analytics. Here is a look at the other 90 startups catching our attention in 2026.