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Top 11 Waltham Startups to Watch in 2026

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Waltham, Massachusetts is a hub for companies in biotechnology and artificial intelligence. The city's startup scene features a mix of established players and newer ventures.

For example, healthcare company Devoted Health has raised $2.3 billion. Meanwhile, robotics pioneer Boston Dynamics continues to be a major presence in the area.

Below is our list of 11 Waltham startups worth keeping an eye on.

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Boston Dynamics builds some of the world's most advanced mobile robots, capable of navigating challenging terrain and automating complex tasks. Their work on dynamic machines like Spot and Atlas has made them a globally recognized leader in robotics.

Year Founded1992
FoundersMarc Raibert
Funding Amount$37M
Startup SizeLarge Team (251-1,000)
Last Funding StatusVenture Round
Top InvestorsSoftBank

Buyers Edge Platform builds a digital procurement network for the foodservice industry. Their data and software tools help operators, distributors, and manufacturers streamline purchasing and make better supply chain decisions.

Year Founded1998
FoundersJohn Davie
Funding Amount$425M
Startup SizeMajor Organization (1,001-5,000)
Last Funding StatusPrivate Equity
Top InvestorsGeneral Atlantic, Bregal Sagemount, Blackstone Tactical Opportunities, Morgan Stanley Tactical Value

Skyhawk Therapeutics builds a new class of small molecule drugs designed to correct RNA expression. The company's therapies target a broad range of diseases, including cancer, neurodegenerative conditions, and rare genetic disorders.

Year Founded2016
FoundersBill Haney, Kathleen McCarthy
Funding Amount$181.2M
Startup SizeMid-Size Team (51-250)
Last Funding StatusVenture Round
Top InvestorsGreatPoint Ventures, Good Growth Capital, Fidelity, Rock Springs Capital, Agent Capital

CallMiner builds an AI-driven conversation intelligence platform to analyze customer interactions, with a primary focus on contact centers. The software automatically transcribes and analyzes conversations to provide insights that help improve agent performance and business operations.

Year Founded2002
FoundersJeff Gallino
Funding Amount$196.6M
Startup SizeLarge Team (251-1,000)
Last Funding StatusVenture Round
Top InvestorsGoldman Sachs, Goldman Sachs Growth Equity, NewSpring, IQT, Inflexion Partners

Scipher Medicine's platform deciphers a patient's unique molecular data to predict how they will respond to specific drugs. Their first test, PrismRA, gives doctors and patients a clearer path for treating rheumatoid arthritis.

Year Founded2014
FoundersAlbert László Barabasi, Joseph Loscalzo, Marcell Veidner, Peter Ruppert
Funding Amount$227M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries D
Top InvestorsAlumni Ventures, Khosla Ventures, Hitachi Ventures, Neuberger Berman, Optum Ventures

Linus Health builds a digital platform that gives healthcare providers tools for the early detection of Alzheimer's and other dementias. The company's technology uses digital cognitive assessments to deliver sensitive insights into brain health, helping to modernize the screening process.

Year Founded2019
FoundersAlvaro Pascual-Leone, David Bates, Seng Oon Toh
Funding Amount$64.9M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries B
Top InvestorsMorningside

Pretzel Therapeutics is creating a new class of therapies designed to reverse mitochondrial dysfunction. The company's platform is built on novel insights into mitochondrial biology to address the root cause of many diseases.

Year Founded2019
FoundersClaes Gustafsson, Gabriel Martinez, Maria Falkenberg, Michal Minczuk
Funding Amount$72.5M
Startup SizeLean Team (11-50)
Last Funding StatusVenture Round
Top InvestorsCambridge Innovation Capital, ARCH Venture Partners, HealthCap, GV, Mubadala Capital Ventures

American Robotics builds AI-powered, pilotless drones that are fully automated for industrial applications. They offer a robot-as-a-service system that was the first to be approved by the FAA for operation without a human pilot on site.

Year Founded2016
FoundersEitan Babcock, Reese Mozer, Vijay Somandepalli
Funding Amount$92M
Startup SizeLean Team (11-50)
Last Funding StatusConvertible Note
Top InvestorsBRC Innovation

Devoted Health provides Medicare Advantage plans that give seniors a more personal healthcare experience. They pair members with a dedicated guide and use technology to simplify navigating the healthcare system.

Year Founded2017
FoundersEdward Park, Todd Park
Funding Amount$2.3B
Startup SizeMajor Organization (1,001-5,000)
Last Funding StatusSeries E
Top InvestorsAndreessen Horowitz, General Catalyst, Oak HC/FT, ICONIQ Growth, Venrock

BostonGene develops a biomedical software platform that uses advanced patient analysis to guide personalized cancer therapies. Their technology integrates molecular and clinical data to help oncologists identify the most effective treatment options for patients.

Year Founded2015
FoundersAndrew Feinberg
Funding Amount$200M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries B
Top InvestorsNEC Corporation, Japan Industrial Partners, Impact Investment Capital

1 Additional Waltham Startup Worth Following

Our top ten picks only scratch the surface of what's happening in Waltham. Other new companies are making big moves, with one biotech startup recently raising $400 million.

This level of investment points to the strong momentum building in the area. Here is another company helping to shape the local startup scene.

StartupIndustryYear FoundedAmount RaisedLast Funding Round
Kailera Therapeutics logo Kailera TherapeuticsBiotech2024$400MSeries A

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