Cambridge is home to 15 unicorn startups, spanning both the Massachusetts and United Kingdom technology hubs. The ecosystem is heavily focused on deep tech sectors like artificial intelligence and biotechnology.
AI medical search company OpenEvidence leads the group with a $6B valuation. UK based CMR Surgical, a robotic surgery firm, has raised over $1.3B in funding.
Below is the full list of 15 Cambridge unicorn startups at this time.
Top 10 Most Valuable Cambridge Unicorns
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Get the Sheet for $50OpenEvidence builds an AI platform that gives medical professionals instant access to evidence-based answers for clinical questions. Their system supports clinical decision-making by synthesizing vast amounts of medical literature, helping practitioners improve patient outcomes.
| Valuation | $6B (Joined February 2025) |
| Year Founded | 2021 |
| Founders | Daniel Nadler, Zachary Ziegler |
| Funding Amount | $517M |
| Company Size | Lean Team (11-50) |
| Last Funding Status | Series C |
| Top Investors | Coatue, Bond, Thrive Capital, Sequoia Capital, Kleiner Perkins |
CMR Surgical builds the Versius robotic system to help surgeons perform minimally invasive keyhole surgery. Their technology is designed to make these complex procedures more accessible and standardized for patients worldwide.
| Valuation | $3B (Joined September 2019) |
| Year Founded | 2014 |
| Founders | Luke Hares, Mark Slack, Martin Frost |
| Funding Amount | $1.3B |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Venture Round |
| Top Investors | GE Healthcare, Ally Bridge Group, Trinity Capital, Lightrock, Cambridge Innovation Capital |
Inari builds next-generation seeds using a combination of AI-powered predictive design and gene editing. Their approach aims to increase crop yields for farmers while reducing the overall environmental footprint of agriculture.
| Valuation | $2.17B (Joined May 2021) |
| Year Founded | 2016 |
| Founders | David Berry, Ignacio Martinez, John Casey |
| Funding Amount | $753M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series G |
| Top Investors | Pavilion Capital, G Squared, Abu Dhabi Investment Authority, Acre Venture Partners, Flagship Pioneering |
Liquid AI develops a new class of general-purpose AI systems based on its breakthrough discovery of liquid neural networks. These highly efficient models are designed to learn continuously from data streams, making them more adaptable than traditional AI.
| Valuation | $2B (Joined December 2024) |
| Year Founded | 2023 |
| Founders | Alexander Amini, Daniela Rus, Mathias Lechner, Ramin Hasani |
| Funding Amount | $293.1M |
| Company Size | Mid-Size Team (51-250) |
| Last Funding Status | Series A |
| Top Investors | Samsung NEXT, Isai, Safar Partners, Bold Capital Partners, Automattic |
ConcertAI provides AI-powered software and real-world data solutions to advance clinical research in oncology. Their technology helps life science companies and healthcare providers analyze real-world evidence to accelerate the development of new cancer therapies.
| Valuation | $2B (Joined March 2022) |
| Year Founded | 2018 |
| Founders | Jeff Elton |
| Funding Amount | $300M |
| Company Size | Major Organization (1,001-5,000) |
| Last Funding Status | Series C |
| Top Investors | Maverick Ventures, Declaration Partners, AllianceBernstein, SymphonyAI, Sixth Street |
Tessera Therapeutics is pioneering Gene Writing™, a new biotechnology that writes in the code of life to treat diseases. Their genome engineering platform can make a wide range of alterations, from small changes to inserting entire genes.
| Valuation | $2B (Joined April 2022) |
| Year Founded | 2018 |
| Founders | Geoffrey von Maltzahn, Jacob Rubens, Noubar Afeyan |
| Funding Amount | $623.1M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Venture Round |
| Top Investors | Flagship Pioneering, Abu Dhabi Investment Authority, Bill & Melinda Gates Foundation, Artis Ventures, Cormorant Asset Management |
Orna Therapeutics develops fully engineered circular RNA to create a new class of medicines. Their novel therapies are designed to be more durable and effective than traditional approaches for treating a wide range of diseases.
| Valuation | $2B (Joined August 2022) |
| Year Founded | 2019 |
| Founders | Alex Wesselhoeft, Daniel Anderson, Raffaella Squilloni |
| Funding Amount | $321M |
| Company Size | Mid-Size Team (51-250) |
| Last Funding Status | Series B |
| Top Investors | Taiho Ventures, MPM Capital, Bristol-Myers Squibb, Kite Pharma, Merck |
Devo offers a cloud-native logging and security analytics platform designed to give organizations full visibility into their data. Their technology empowers security teams to analyze vast datasets in real-time, enabling them to act confidently against threats.
| Valuation | $2B |
| Year Founded | 2011 |
| Founders | Pedro Castillo |
| Funding Amount | $481M |
| Company Size | Mid-Size Team (51-250) |
| Last Funding Status | Series F |
| Top Investors | Georgian, TCV, Bessemer Venture Partners, Insight Partners, General Atlantic |
Cambridge Mobile Telematics created the DriveWell platform, a telematics solution that uses smartphone sensors to analyze driving behavior. Their technology provides data and feedback to drivers and partners like auto insurers to improve road safety and reduce accidents.
| Valuation | $1.5B (Joined December 2018) |
| Year Founded | 2010 |
| Founders | Bill Powers, Hari Balakrishnan, Samuel Madden |
| Funding Amount | $502.5M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Private Equity |
| Top Investors | SoftBank Vision Fund |
Lila Sciences creates a scientific superintelligence platform to operate autonomous labs for research. Their system accelerates discovery within the fields of life sciences, chemistry, and materials science.
| Valuation | $1.23B (Joined February 2021) |
| Year Founded | 2023 |
| Founders | Molly Gibson, Noubar Afeyan |
| Funding Amount | $550M |
| Company Size | Mid-Size Team (51-250) |
| Last Funding Status | Series A |
| Top Investors | Catalio Capital Management, Flagship Pioneering, General Catalyst, Alumni Ventures, NVentures |
The Remaining 5 Unicorns Founded in Cambridge
The ten most valuable unicorns are just one part of Cambridge's story. The city's other billion-dollar companies are working in fields from AI to energy, raising nearly $4 billion between them.
These startups are a key reason the local tech scene is so exciting. Below are the rest of the companies that have reached the unicorn milestone.