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The Full List of 15 Unicorn Startups in Cambridge (2026)

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Cambridge is home to 15 unicorn startups, spanning both the Massachusetts and United Kingdom technology hubs. The ecosystem is heavily focused on deep tech sectors like artificial intelligence and biotechnology.

AI medical search company OpenEvidence leads the group with a $6B valuation. UK based CMR Surgical, a robotic surgery firm, has raised over $1.3B in funding.

Below is the full list of 15 Cambridge unicorn startups at this time.

Top 10 Most Valuable Cambridge Unicorns

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OpenEvidence builds an AI platform that gives medical professionals instant access to evidence-based answers for clinical questions. Their system supports clinical decision-making by synthesizing vast amounts of medical literature, helping practitioners improve patient outcomes.

Valuation$6B (Joined February 2025)
Year Founded2021
FoundersDaniel Nadler, Zachary Ziegler
Funding Amount$517M
Company SizeLean Team (11-50)
Last Funding StatusSeries C
Top InvestorsCoatue, Bond, Thrive Capital, Sequoia Capital, Kleiner Perkins

CMR Surgical builds the Versius robotic system to help surgeons perform minimally invasive keyhole surgery. Their technology is designed to make these complex procedures more accessible and standardized for patients worldwide.

Valuation$3B (Joined September 2019)
Year Founded2014
FoundersLuke Hares, Mark Slack, Martin Frost
Funding Amount$1.3B
Company SizeLarge Team (251-1,000)
Last Funding StatusVenture Round
Top InvestorsGE Healthcare, Ally Bridge Group, Trinity Capital, Lightrock, Cambridge Innovation Capital

Inari builds next-generation seeds using a combination of AI-powered predictive design and gene editing. Their approach aims to increase crop yields for farmers while reducing the overall environmental footprint of agriculture.

Valuation$2.17B (Joined May 2021)
Year Founded2016
FoundersDavid Berry, Ignacio Martinez, John Casey
Funding Amount$753M
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries G
Top InvestorsPavilion Capital, G Squared, Abu Dhabi Investment Authority, Acre Venture Partners, Flagship Pioneering

Liquid AI develops a new class of general-purpose AI systems based on its breakthrough discovery of liquid neural networks. These highly efficient models are designed to learn continuously from data streams, making them more adaptable than traditional AI.

Valuation$2B (Joined December 2024)
Year Founded2023
FoundersAlexander Amini, Daniela Rus, Mathias Lechner, Ramin Hasani
Funding Amount$293.1M
Company SizeMid-Size Team (51-250)
Last Funding StatusSeries A
Top InvestorsSamsung NEXT, Isai, Safar Partners, Bold Capital Partners, Automattic

ConcertAI provides AI-powered software and real-world data solutions to advance clinical research in oncology. Their technology helps life science companies and healthcare providers analyze real-world evidence to accelerate the development of new cancer therapies.

Valuation$2B (Joined March 2022)
Year Founded2018
FoundersJeff Elton
Funding Amount$300M
Company SizeMajor Organization (1,001-5,000)
Last Funding StatusSeries C
Top InvestorsMaverick Ventures, Declaration Partners, AllianceBernstein, SymphonyAI, Sixth Street

Tessera Therapeutics is pioneering Gene Writing™, a new biotechnology that writes in the code of life to treat diseases. Their genome engineering platform can make a wide range of alterations, from small changes to inserting entire genes.

Valuation$2B (Joined April 2022)
Year Founded2018
FoundersGeoffrey von Maltzahn, Jacob Rubens, Noubar Afeyan
Funding Amount$623.1M
Company SizeLarge Team (251-1,000)
Last Funding StatusVenture Round
Top InvestorsFlagship Pioneering, Abu Dhabi Investment Authority, Bill & Melinda Gates Foundation, Artis Ventures, Cormorant Asset Management

Orna Therapeutics develops fully engineered circular RNA to create a new class of medicines. Their novel therapies are designed to be more durable and effective than traditional approaches for treating a wide range of diseases.

Valuation$2B (Joined August 2022)
Year Founded2019
FoundersAlex Wesselhoeft, Daniel Anderson, Raffaella Squilloni
Funding Amount$321M
Company SizeMid-Size Team (51-250)
Last Funding StatusSeries B
Top InvestorsTaiho Ventures, MPM Capital, Bristol-Myers Squibb, Kite Pharma, Merck

Devo offers a cloud-native logging and security analytics platform designed to give organizations full visibility into their data. Their technology empowers security teams to analyze vast datasets in real-time, enabling them to act confidently against threats.

Valuation$2B
Year Founded2011
FoundersPedro Castillo
Funding Amount$481M
Company SizeMid-Size Team (51-250)
Last Funding StatusSeries F
Top InvestorsGeorgian, TCV, Bessemer Venture Partners, Insight Partners, General Atlantic

Cambridge Mobile Telematics created the DriveWell platform, a telematics solution that uses smartphone sensors to analyze driving behavior. Their technology provides data and feedback to drivers and partners like auto insurers to improve road safety and reduce accidents.

Valuation$1.5B (Joined December 2018)
Year Founded2010
FoundersBill Powers, Hari Balakrishnan, Samuel Madden
Funding Amount$502.5M
Company SizeLarge Team (251-1,000)
Last Funding StatusPrivate Equity
Top InvestorsSoftBank Vision Fund

Lila Sciences creates a scientific superintelligence platform to operate autonomous labs for research. Their system accelerates discovery within the fields of life sciences, chemistry, and materials science.

Valuation$1.23B (Joined February 2021)
Year Founded2023
FoundersMolly Gibson, Noubar Afeyan
Funding Amount$550M
Company SizeMid-Size Team (51-250)
Last Funding StatusSeries A
Top InvestorsCatalio Capital Management, Flagship Pioneering, General Catalyst, Alumni Ventures, NVentures

The Remaining 5 Unicorns Founded in Cambridge

The ten most valuable unicorns are just one part of Cambridge's story. The city's other billion-dollar companies are working in fields from AI to energy, raising nearly $4 billion between them.

These startups are a key reason the local tech scene is so exciting. Below are the rest of the companies that have reached the unicorn milestone.

Unicorn StartupMain IndustryYear FoundedAmount RaisedValuation
Suno logo SunoAI2022$375M$2.45B
Commonwealth Fusion Systems logo Commonwealth Fusion SystemsEnergy2017$2.9B$1B
Solo.io logo Solo.ioMedia2017$171.5M$1B
Insilico Medicine logo Insilico MedicineAI2014$624.3M$1B
24M Technologies logo 24M TechnologiesHardware2010$184.8M$1B

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