The chemical industry is seeing new companies tackle big problems like sustainability and material science. These startups are developing new ways to create everything from batteries to cement.
Group14 Technologies has raised $1.2B for its advanced battery technology. Another company, CuspAI, was founded in 2024 and has already secured $130M to use AI for material discovery.
Below is our list of 77 Chemical startups worth keeping an eye on.
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Get the Sheet for $50CuspAI is building a platform that uses generative AI to design and discover new materials for a wide range of applications. Their technology focuses on creating materials that can help solve major global challenges, including carbon capture and storage.
| Headquarters | Cambridge, Cambridgeshire, United Kingdom |
| Year Founded | 2024 |
| Founders | Alyn Chad Edwards, Chad Edwards, Max Welling |
| Funding Amount | $130M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series A |
| Top Investors | Temasek Holdings, Lightspeed Venture Partners, Samsung Electronics, Northzone, LocalGlobe |
Group14 Technologies manufactures advanced silicon battery technology that serves as a drop-in replacement for graphite anodes. Their silicon-carbon composite material helps manufacturers create more powerful and faster-charging lithium-ion batteries for electric vehicles and consumer electronics.
| Headquarters | Woodinville, Washington, United States |
| Year Founded | 2015 |
| Founders | Aaron Feaver, Rick Costantino, Rick Luebbe |
| Funding Amount | $1.2B |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Series D |
| Top Investors | Lightrock, OMERS Ventures, Yaletown Partners, Decarbonization Partners, Vsquared Ventures |
Arzeda designs and manufactures custom proteins and enzymes for use in pharmaceuticals and industrial chemicals. Their work is powered by an AI and machine learning platform that enables the creation of novel biological components.
| Headquarters | Seattle, Washington, United States |
| Year Founded | 2009 |
| Founders | Alexandre Zanghellini, Daniela Grabs, David Baker, Eric Althoff |
| Funding Amount | $108.1M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Grant |
| Top Investors | National Science Foundation, Casdin Capital, Sofinnova Partners, Universal Materials Incubator, Circulate Capital |
OXCCU tackles industrial emissions by converting captured carbon dioxide and hydrogen into useful materials. Their technology produces sustainable aviation fuels, chemicals, and biodegradable plastics, offering a new decarbonization pathway for hard-to-abate industries.
| Headquarters | Oxford, Oxfordshire, United Kingdom |
| Year Founded | 2021 |
| Founders | Andrew Symes, Benzhen Yao, Jane Jin, Peter Edward, Tiancun Xiao |
| Funding Amount | $54.1M |
| Startup Size | Founding Team (1-10) |
| Last Funding Status | Series B |
| Top Investors | Aramco Ventures, Trafigura, Clean Energy Ventures, Hostplus, IP Group |
Nitricity creates nitrogen fertilizer using a process powered by only air, water, and renewable energy. Their technology provides a climate-friendly fertilizer for farmers, helping to decarbonize a critical part of the agricultural supply chain.
| Headquarters | Fremont, California, United States |
| Year Founded | 2018 |
| Founders | Jay Schwalbe, Joshua McEnaney, Nicolas Pinkowski |
| Funding Amount | $90.9M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series B |
| Top Investors | National Science Foundation, Alumni Ventures, Khosla Ventures, Lowercarbon Capital, Bossa Invest |
Cylib developed a proprietary recycling process for end-of-life batteries and production scrap. Their technology transforms this waste into marketable raw materials, helping to build a circular economy for the battery industry.
| Headquarters | Aachen, Nordrhein-Westfalen, Germany |
| Year Founded | 2022 |
| Founders | — |
| Funding Amount | $92.7M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Grant |
| Top Investors | Speedinvest, 10x Founders, Bosch Ventures, Vsquared Ventures, Porsche Ventures |
Vantage Specialty Chemicals creates specialty ingredients derived from natural sources for the personal care and industrial markets. Their portfolio of chemicals provides the building blocks for products ranging from cosmetics to industrial lubricants.
| Headquarters | Chicago, Illinois, United States |
| Year Founded | 2008 |
| Founders | — |
| Funding Amount | $900M |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Debt Financing |
| Top Investors | Apollo, Silver Point Capital, L.P. |
Twelve has developed a carbon transformation technology that converts captured CO₂ into essential products. Their process creates sustainable alternatives to fossil fuels, including chemicals and aviation fuel, directly from the air.
| Headquarters | Berkeley, California, United States |
| Year Founded | 2015 |
| Founders | Etosha Cave, Kendra Kuhl, Nicholas Flanders |
| Funding Amount | $929.4M |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Venture Round |
| Top Investors | National Science Foundation, TPG, Techstars, Greycroft, Global Brain Corporation |
FREDsense develops portable field kits that allow industries to quickly analyze water quality on-site. Their sensor technology provides rapid, lab-grade results directly to the people who need them, bypassing traditional laboratory wait times.
| Headquarters | Calgary, Alberta, Canada |
| Year Founded | 2014 |
| Founders | David Lloyd, Emily Hicks, Iain George, Lisa Oberding, Robert Mayall |
| Funding Amount | $10M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series A |
| Top Investors | Elemental Impact, Emerald Technology Ventures, Creative Destruction Lab (CDL), FundersClub, Accelerate Fund |
Fortera produces zero CO₂ cement for the construction industry through its proprietary ReCarb process. This system captures emissions directly from cement plants and mineralizes the CO₂ into a ready-to-use cementitious material.
| Headquarters | San Jose, California, United States |
| Year Founded | 2007 |
| Founders | Michael Weiss, Ryan Gilliam, Samir Kaul |
| Funding Amount | $175.5M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Venture Round |
| Top Investors | Temasek Holdings, Alumni Ventures, Khosla Ventures, Hercules Capital, Wollemi |
67 Additional Chemical Startups Worth Following
Those top 10 companies are a great snapshot, but there's a much bigger picture. Together, the startups below have raised billions to tackle challenges in manufacturing, biotech, and climate.
Some are new and scrappy, while others are already scaling up fast. Here is a look at the other chemical startups to keep an eye on.