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San Diego has established itself as a key hub for biotechnology startups. The local ecosystem is defined by companies developing new medical and life science technologies.
Avenzo Therapeutics, a cancer therapy developer founded in 2022, has already raised $841.9M. This level of investment is also seen in other fields, with security company Drata raising over $328M.
Below is our list of 47 San Diego startups worth keeping an eye on.
Everything you need to raise funding for your startup, including 3,500+ investors, 7 tools, 18 templates and 3 learning resources.
Buy It For $97 $297 →Information about the industries, countries, and cities they generally invest in.
Get the Sheet for $50Information about their valuation, HQ's location, founded year, name of founders, funding amount and number of employees.
Get the Sheet for $50List of startup investors in the BioTech, Health, and Medicine industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50List of 250 startup investors in the AI and Machine Learning industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50List of 250 startup investors in the FinTech and Finance industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50Avenzo Therapeutics develops novel oncology therapies for difficult-to-treat cancers. Their work is centered on advancing a pipeline of clinical-stage treatments to provide new options for patients.
Debut develops novel ingredients and formulations for the beauty industry using biotechnology. Their platform produces high-performance, sustainable alternatives to traditional cosmetic components.
Cordial builds a cross-channel marketing and data platform that helps marketers use their customer data to send highly personalized messages. The platform enables brands to connect with their audience through email, SMS, and mobile apps in real time.
Element Biosciences develops innovative genetic analysis tools for the research and diagnostic markets. Their core product, the AVITI System, is a benchtop DNA sequencing platform that provides scientists with more accessible and powerful genomic capabilities.
Drata builds a trust management platform that helps companies automate their security compliance and risk management. Their software streamlines the process of achieving and maintaining certifications like SOC 2 and ISO 27001 through continuous monitoring.
VedaBio has developed a diagnostics platform capable of near-instant molecular detection. Their breakthrough technology combines the accuracy of PCR with the speed of antigen tests.
Sempra Infrastructure develops, builds, and operates the large-scale infrastructure critical to the world's energy needs. Their portfolio includes LNG terminals, clean power projects, and energy networks aimed at advancing both energy security and climate goals.
Lytx develops video telematics solutions that help fleet managers improve driver safety and operational efficiency. They combine machine vision and artificial intelligence to detect risky driving behaviors and provide actionable insights for fleet operators.
ADARx Pharmaceuticals develops genetic medicines using a technology that precisely edits mRNA transcripts. This approach allows them to create RNA-targeting therapeutics designed to address a wide variety of diseases.
Radicle Science operates a health tech platform that runs clinical trials for supplements and other wellness products. This provides brands with a faster, non-FDA route to scientifically validate their product’s effectiveness.
The top 10 are just a small slice of what’s happening in San Diego. Founders in fields like biotech and AI are especially active, collectively raising billions in funding.
Some of these companies are just getting started, while others have been growing for years. Here’s a look at the rest of the startups shaping the city's ecosystem.
| Startup | Industry | Year Founded | Amount Raised | Last Funding Round |
|---|---|---|---|---|
| Enterprise | 2017 | $82M | Series C | |
| AI | 2018 | $22.2M | Debt Financing | |
| Analytics | 2008 | $263.9M | Venture Round | |
| AI | 2019 | $203M | Series B | |
| Sports | 1995 | $52.6M | Series C | |
| Biotech | 2020 | $46M | Series A | |
| Biotech | 2020 | $13.8M | Grant | |
| Analytics | 2016 | $87M | Series D | |
| Retail | 2002 | $150M | Venture Round | |
| Biotech | 2013 | $369.8M | Series B | |
| AI | 2015 | $1.3B | Series F | |
| Education | 2021 | $10M | Seed | |
| Sports | 2019 | $163.8M | Venture Round | |
| Biotech | 2012 | $276.3M | Series C | |
| AI | 2017 | $15.1M | Seed | |
| Manufacturing | 2014 | $12M | Series A | |
| Biotech | 2025 | $205M | Series A | |
| Enterprise | 2000 | $152.5M | Private Equity | |
| Marketing | 2015 | $30M | Series A | |
| Energy | 2018 | $23M | Series B | |
| Marketing | 2012 | $237.8M | Venture Round | |
| Biotech | 2024 | $370M | Series A | |
| Mobility | 2022 | $67.5M | Series A | |
| Healthcare | 2016 | $58.5M | Series B | |
| Biotech | 2022 | $66.3M | Series A | |
| Enterprise | 2021 | $10k | Pre-Seed | |
| Biotech | 2021 | $340M | Series B | |
| Logistics | 2014 | $8M | Seed | |
| Biotech | 2018 | $45.1M | Seed | |
| Biotech | 2016 | $17.4M | Debt Financing | |
| Biotech | 2020 | $173M | Series B | |
| AI | 2020 | $67.7M | Series B | |
| Biotech | 2018 | $32.1M | Series A | |
| Biotech | 2018 | $225.1M | Series C | |
| Analytics | 2010 | $446.5M | Debt Financing | |
| Healthcare | 2023 | $10.2M | Seed | |
| Other | 2022 | — | — |
