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Download The List of the 100 Highest-Valued Unicorns

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The Full List of 9 Unicorn Startups in San Diego (2026)

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San Diego is home to nine unicorn companies, with a strong focus on biotechnology and software.

Biosplice Therapeutics leads them with a valuation of $12B. Another company, Drata, reached a $2B valuation shortly after its founding in 2020.

Below is the full list of 9 San Diego unicorn startups at this time.

Top 9 Most Valuable San Diego Unicorns

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Biosplice Therapeutics develops first-in-class, small-molecule drugs based on the science of alternative splicing. Their research focuses on creating new treatments for major conditions like osteoarthritis and cancer.

Valuation$12B
Year Founded2008
FoundersOsman Kibar
Funding Amount$778M
Company SizeMid-Size Team (51-250)
Last Funding StatusVenture Round
Top InvestorsVickers Venture Partners, aMoon Fund, Verition Fund Management, Sands Capital Ventures, Swicorp

Shield AI builds an artificial intelligence pilot that can fly everything from quadcopters to fighter jets. Their autonomous systems are created to protect service members and civilians without putting them in harm's way.

Valuation$5.3B (Joined August 2021)
Year Founded2015
FoundersAndrew Reiter, Brandon Tseng, Ryan Tseng
Funding Amount$1.3B
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries F
Top InvestorsAndreessen Horowitz, US Innovative Technology Fund, Founder Collective, ARK Investment Management, Riot Ventures

ClickUp builds a comprehensive productivity platform designed to consolidate all work into a single application. Their highly customizable software combines tasks, docs, goals, and chat, allowing teams to manage projects and collaborate from one central hub.

Valuation$4B (Joined December 2020)
Year Founded2017
FoundersAlex Yurkowski, Zeb Evans
Funding Amount$537.5M
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries C
Top InvestorsGeorgian, Andreessen Horowitz, Craft Ventures, Lightspeed Venture Partners, Tiger Global Management

Seismic develops an AI-powered platform that equips sales, marketing, and customer success teams with the tools to drive revenue growth. They are known for a comprehensive enablement solution that unifies content management, team coaching, and performance analytics in one place.

Valuation$3B (Joined December 2018)
Year Founded2010
FoundersEd Calnan, Fred Xie, J. Douglas Winter, Marc Romano, Nasser Barghouti
Funding Amount$446.5M
Company SizeMajor Organization (1,001-5,000)
Last Funding StatusSeries G
Top InvestorsGeneral Atlantic, T. Rowe Price, JMI Equity, Lightspeed Venture Partners, Permira

Drata provides a trust management platform that puts security and compliance workflows on autopilot. Their system helps companies streamline risk management and maintain continuous security assurance, which is essential for building and maintaining customer trust.

Valuation$2B (Joined November 2021)
Year Founded2020
FoundersAdam Markowitz, Daniel Marashlian, Troy Markowitz
Funding Amount$328.2M
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries C
Top InvestorsICONIQ Growth, SV Angel, Basis Set Ventures, Ballistic Ventures, Salesforce Ventures

Netradyne builds fleet safety technology using computer vision and deep data analysis to improve driver performance. Their Driveri platform uses an AI-powered camera system to provide a complete view of the driving day, helping to reduce risk and recognize safe driving habits.

Valuation$1.34B (Joined January 2025)
Year Founded2015
FoundersAvneesh Agrawal, David Julian
Funding Amount$352.5M
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries D
Top InvestorsGeodesic Capital, SoftBank Vision Fund, Pavilion Capital, Reliance Industries, Point72 Ventures

Tealium provides a customer data platform that connects and standardizes data from web, mobile, and offline sources. Their tools create a unified, real-time view of the customer, allowing businesses to orchestrate more personalized marketing and analytics.

Valuation$1.2B (Joined February 2021)
Year Founded2008
FoundersAli Behnam, Mike Anderson
Funding Amount$263.9M
Company SizeLarge Team (251-1,000)
Last Funding StatusVenture Round
Top InvestorsBattery Ventures, Industry Ventures, Georgian, Bain Capital, Bain Capital Ventures

Element Biosciences builds advanced genetic analysis tools for the life science sector. Their AVITI System is a benchtop sequencing platform designed to give research and diagnostic markets a more flexible and cost-effective tool for DNA and RNA sequencing.

Valuation$1B
Year Founded2017
FoundersMatt Kellinger, Michael Previte, Molly He
Funding Amount$678M
Company SizeLarge Team (251-1,000)
Last Funding StatusSeries D
Top InvestorsSamsung Electronics, Wellington Management, Venrock, RA Capital Management, Fidelity

Human Longevity created a health intelligence platform that uses genomic sequencing and advanced diagnostics for proactive healthcare. Their approach provides a comprehensive, data-driven view of an individual's health to help manage and extend a healthy lifespan.

Valuation$1B
Year Founded2013
FoundersElizabeth Hunker, J. Craig Venter, Peter Diamandis, Robert J. Hariri
Funding Amount$369.8M
Company SizeMid-Size Team (51-250)
Last Funding StatusSeries B
Top InvestorsIllumina, Threshold, Amino Capital, Illumina Ventures, TVM Capital Healthcare

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