San Diego is home to nine unicorn companies, with a strong focus on biotechnology and software.
Biosplice Therapeutics leads them with a valuation of $12B. Another company, Drata, reached a $2B valuation shortly after its founding in 2020.
Below is the full list of 9 San Diego unicorn startups at this time.
Top 9 Most Valuable San Diego Unicorns
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2,189 Accelerators & Incubators
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1,600+ Unicorns
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250 BioTech & Health Investors
List of startup investors in the BioTech, Health, and Medicine industries, along with their Twitter, LinkedIn, and email addresses.
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250 AI Investors
List of 250 startup investors in the AI and Machine Learning industries, along with their Twitter, LinkedIn, and email addresses.
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250 Fintech Investors
List of 250 startup investors in the FinTech and Finance industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50Biosplice Therapeutics develops first-in-class, small-molecule drugs based on the science of alternative splicing. Their research focuses on creating new treatments for major conditions like osteoarthritis and cancer.
| Valuation | $12B |
| Year Founded | 2008 |
| Founders | Osman Kibar |
| Funding Amount | $778M |
| Company Size | Mid-Size Team (51-250) |
| Last Funding Status | Venture Round |
| Top Investors | Vickers Venture Partners, aMoon Fund, Verition Fund Management, Sands Capital Ventures, Swicorp |
Shield AI builds an artificial intelligence pilot that can fly everything from quadcopters to fighter jets. Their autonomous systems are created to protect service members and civilians without putting them in harm's way.
| Valuation | $5.3B (Joined August 2021) |
| Year Founded | 2015 |
| Founders | Andrew Reiter, Brandon Tseng, Ryan Tseng |
| Funding Amount | $1.3B |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series F |
| Top Investors | Andreessen Horowitz, US Innovative Technology Fund, Founder Collective, ARK Investment Management, Riot Ventures |
ClickUp builds a comprehensive productivity platform designed to consolidate all work into a single application. Their highly customizable software combines tasks, docs, goals, and chat, allowing teams to manage projects and collaborate from one central hub.
| Valuation | $4B (Joined December 2020) |
| Year Founded | 2017 |
| Founders | Alex Yurkowski, Zeb Evans |
| Funding Amount | $537.5M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series C |
| Top Investors | Georgian, Andreessen Horowitz, Craft Ventures, Lightspeed Venture Partners, Tiger Global Management |
Seismic develops an AI-powered platform that equips sales, marketing, and customer success teams with the tools to drive revenue growth. They are known for a comprehensive enablement solution that unifies content management, team coaching, and performance analytics in one place.
| Valuation | $3B (Joined December 2018) |
| Year Founded | 2010 |
| Founders | Ed Calnan, Fred Xie, J. Douglas Winter, Marc Romano, Nasser Barghouti |
| Funding Amount | $446.5M |
| Company Size | Major Organization (1,001-5,000) |
| Last Funding Status | Series G |
| Top Investors | General Atlantic, T. Rowe Price, JMI Equity, Lightspeed Venture Partners, Permira |
Drata provides a trust management platform that puts security and compliance workflows on autopilot. Their system helps companies streamline risk management and maintain continuous security assurance, which is essential for building and maintaining customer trust.
| Valuation | $2B (Joined November 2021) |
| Year Founded | 2020 |
| Founders | Adam Markowitz, Daniel Marashlian, Troy Markowitz |
| Funding Amount | $328.2M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series C |
| Top Investors | ICONIQ Growth, SV Angel, Basis Set Ventures, Ballistic Ventures, Salesforce Ventures |
Netradyne builds fleet safety technology using computer vision and deep data analysis to improve driver performance. Their Driveri platform uses an AI-powered camera system to provide a complete view of the driving day, helping to reduce risk and recognize safe driving habits.
| Valuation | $1.34B (Joined January 2025) |
| Year Founded | 2015 |
| Founders | Avneesh Agrawal, David Julian |
| Funding Amount | $352.5M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series D |
| Top Investors | Geodesic Capital, SoftBank Vision Fund, Pavilion Capital, Reliance Industries, Point72 Ventures |
Tealium provides a customer data platform that connects and standardizes data from web, mobile, and offline sources. Their tools create a unified, real-time view of the customer, allowing businesses to orchestrate more personalized marketing and analytics.
| Valuation | $1.2B (Joined February 2021) |
| Year Founded | 2008 |
| Founders | Ali Behnam, Mike Anderson |
| Funding Amount | $263.9M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Venture Round |
| Top Investors | Battery Ventures, Industry Ventures, Georgian, Bain Capital, Bain Capital Ventures |
Element Biosciences builds advanced genetic analysis tools for the life science sector. Their AVITI System is a benchtop sequencing platform designed to give research and diagnostic markets a more flexible and cost-effective tool for DNA and RNA sequencing.
| Valuation | $1B |
| Year Founded | 2017 |
| Founders | Matt Kellinger, Michael Previte, Molly He |
| Funding Amount | $678M |
| Company Size | Large Team (251-1,000) |
| Last Funding Status | Series D |
| Top Investors | Samsung Electronics, Wellington Management, Venrock, RA Capital Management, Fidelity |
Human Longevity created a health intelligence platform that uses genomic sequencing and advanced diagnostics for proactive healthcare. Their approach provides a comprehensive, data-driven view of an individual's health to help manage and extend a healthy lifespan.
| Valuation | $1B |
| Year Founded | 2013 |
| Founders | Elizabeth Hunker, J. Craig Venter, Peter Diamandis, Robert J. Hariri |
| Funding Amount | $369.8M |
| Company Size | Mid-Size Team (51-250) |
| Last Funding Status | Series B |
| Top Investors | Illumina, Threshold, Amino Capital, Illumina Ventures, TVM Capital Healthcare |