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Top 29 Santiago Startups to Watch in 2026

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Santiago has become a center for new business growth. The city's startup scene shows tons of activity in fields ranging from energy and financial technology to software as a service.

Companies like HIF Global are leading in the energy sector, having raised $480M for its eFuel production. Others, such as the wellness platform Betterfly, have also secured major funding with $204.5M raised to date.

Below is our list of 29 Santiago startups worth keeping an eye on.

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HIF Global produces carbon-neutral eFuels that can power existing cars, ships, and planes without modifications. The company creates its synthetic gasoline substitute by combining green hydrogen with recycled carbon dioxide.

Year Founded2019
Founders
Funding Amount$480M
Startup SizeMid-Size Team (51-250)
Last Funding StatusCorporate Round
Top InvestorsBaker Hughes, Porsche, EIG Global Energy Partners(EIG), Mitsui O.S.K. Lines, Idemitsu Kosan

AgendaPro builds management software for businesses in the beauty and wellness industries to handle online bookings and payments. Their platform gives owners a single tool for scheduling appointments, charging customers, and managing client details.

Year Founded2014
FoundersJulio Guzmán, Matías Ulloa, Nicolás Rossi, Sebastián Hevia
Funding Amount$42.8M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries B
Top InvestorsY Combinator, Riverwood Capital, Kayyak Ventures, Fen Ventures, CORFO

Buk develops a comprehensive, cloud-based platform for human resource management. Their software centralizes a wide range of HR functions, including payroll, talent management, and employee benefits, into one unified system.

Year Founded2016
FoundersFelipe Sateler, Jaime Arrieta Boetsch, Ricardo Sateler, Santiago Lira, Teresita Moran Ovalle
Funding Amount$135M
Startup SizeMajor Organization (1,001-5,000)
Last Funding StatusSeries B
Top InvestorsBase10 Partners, Headline, Endeavor Catalyst, SoftBank, Workday Ventures

Betterfly builds a purpose-driven wellbeing platform that converts healthy habits into charitable donations. Their system also rewards employees with life insurance coverage that grows at no cost as they engage in healthy activities.

Year Founded2018
FoundersCristobal della Maggiora, Eduardo della Maggiora
Funding Amount$204.5M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries C
Top InvestorsQED Investors, Endeavor Catalyst, Lightrock, VentureSouq, Greycroft

Toku builds a payment recovery platform for subscription-based companies in Latin America. Their software automates the collection process to reduce customer churn and recover revenue from failed payments.

Year Founded2020
FoundersCristina Etcheberry, Francisca Noguera Astaburuaga
Funding Amount$66.5M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries A
Top InvestorsOak HC/FT, Y Combinator, Clocktower Technology Ventures, F-Prime, FundersClub

Engie Energia Chile generates and supplies electricity throughout the country and manages natural gas transportation. They operate a diverse portfolio that includes both conventional energy infrastructure and a growing number of renewable energy projects.

Year Founded1981
Founders
Funding Amount$400M
Startup SizeMajor Organization (1,001-5,000)
Last Funding StatusDebt Financing
Top InvestorsInternational Finance Corporation, ILX

PhageLab develops bacteriophage-based solutions to control bacterial diseases in animal production. Their technology provides a natural alternative to antibiotics, helping to improve both animal welfare and food safety.

Year Founded2009
FoundersDiego Belmar, Hans Pieringer, Nico Ferre, Nicolas Ferreira, Pablo Cifuentes
Funding Amount$41M
Startup SizeLean Team (11-50)
Last Funding StatusVenture Round
Top InvestorsKaszek, Collaborative Fund, The Yield Lab LATAM, Start-Up Chile, Humboldt Fund

Colektia builds a digital platform that helps financial institutions create new collections models based on artificial intelligence. Their software is designed to automate and optimize the debt recovery process through more efficient digital strategies.

Year Founded2018
FoundersGabriel Monroy, Oswaldo Monroy
Funding Amount$14.1M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries B
Top InvestorsEndeavor, Wayra, Village Capital, devlabs, Angel Ventures

Wherex builds an AI-driven platform that automates the procurement process for B2B companies. Their software cuts down on repetitive tasks, allowing procurement teams to focus on more strategic, high-impact decisions.

Year Founded2016
FoundersBenjamin Garcia, Felipe Manterola Gana, Francisco Puente, Juan Carlos Hurtado Cruzat
Funding Amount$7.5M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeed
Top InvestorsFJ Labs, Kayyak Ventures, Wollef Ventures, Tuesday Capital, DVC

Talana created a Human Capital Management platform to help companies manage their workforce more efficiently. The software integrates key functions like payroll processing and digital signatures into one easy-to-use system.

Year Founded2016
FoundersJosé Antonio Akel, Pablo de la Barra
Funding Amount$8.1M
Startup SizeLarge Team (251-1,000)
Last Funding StatusVenture Round
Top InvestorsStart-Up Chile, Altis, Venturance Alternative Assets, Venturance

19 Additional Santiago Startups Worth Following

Our top picks only scratch the surface of what’s happening in Santiago. Founders are tackling big challenges in fields like fintech and agtech, and have raised over $140 million to grow their ideas.

Some companies are just getting started, while others are already scaling up. Here’s a look at more startups that are shaping the city's ecosystem.

StartupIndustryYear FoundedAmount RaisedLast Funding Round
Exacta BioScience logo Exacta BioScienceAgTech2019$1.3MSeed
Webdox logo WebdoxCloud2017$11.3MVenture Round
TIMining logo TIMiningInfrastructure2011$13.8MSeries B
SPOT logo SPOTAnalytics2018$3.1MSeed
Shinkansen logo ShinkansenFintech2022$4.1MSeed
Reuse logo ReuseMarketplace2018$6.2MSeed
Instacrops logo InstacropsAgTech2014$3.1M
Justo logo JustoRetail2018$2.6MSeed
Remote Waters logo Remote WatersManufacturing2018$795kGrant
Encuadrado logo EncuadradoFintech2019$1.6MSeed
Loads logo LoadsAgTech2022$8.1MVenture Round
ComparaOnline logo ComparaOnlineEnterprise2009$33.1MSeries C
Poliglota logo PoliglotaEducation2011$4.4MEquity Crowdfunding
Creditú logo CreditúFintech2017R$100MVenture Round
BioElements logo BioElementsBiotech2014$30MSeries A
Bemmbo logo BemmboFintech2022$600kPre-Seed
Get on Board logo Get on BoardEnterprise2014$600kSeed
Hackmetrix logo HackmetrixSecurity2017$3MConvertible Note
Rocketbot logo RocketbotAI2018$2.1MSeed
Inverbis Analytics logo Inverbis AnalyticsAnalytics2020$536.7kSeed

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