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Top 6 Baltimore Startups to Watch in 2026

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Baltimore's startup landscape is heavily defined by the health and biotechnology industries. Companies in this space are attracting considerable capital for growth.

Health care provider AbsoluteCARE has raised $252M to expand its services. Following this trend, b.well Connected Health secured $118.8M for its digital health platform.

Below is our list of 6 Baltimore startups worth keeping an eye on.

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EcoMap Technologies builds an AI-powered platform that enables organizations to create a central, digital hub for their ecosystem. Their software automatically aggregates data on people, resources, and organizations to make information more accessible for communities and industries.

Year Founded2018
FoundersAnthony Caesar, Pava LaPere, Sherrod Davis
Funding Amount$14.3M
Startup SizeLean Team (11-50)
Last Funding StatusUndisclosed
Top InvestorsTEDCO, Techstars, Las Olas Venture Capital, Cofounders Capital, Conscious Venture Lab

b.well Connected Health built a digital platform that gives individuals a single, comprehensive view of their health data. Their system pulls together information from doctors, labs, and insurance plans to help people manage their own healthcare journey.

Year Founded2015
FoundersBryan Jones, Kristen Valdes
Funding Amount$118.8M
Startup SizeMid-Size Team (51-250)
Last Funding StatusDebt Financing
Top InvestorsTrinity Capital, Portfolia, Capital Factory, RTI International, Keiretsu Capital

Rapafusyn Pharmaceuticals develops a novel class of therapeutics using natural product-like macrocycles. They license this proprietary technology to partners, aiming to accelerate the discovery of new medicines for various diseases.

Year Founded2015
Founders
Funding Amount$44M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top Investors3E Bioventures, Lapam Capital, BioTrack Capital, Yonjin Venture, Prox Ventures

Haystack Oncology created a highly sensitive liquid biopsy technology to find trace amounts of cancer after initial treatment. Their platform analyzes circulating tumor DNA, giving doctors critical information to guide personalized follow-up care for patients.

Year Founded2021
FoundersBert Vogelstein, Dan Edelstein, Kenneth Kinzler, Nickolas Papadopoulos
Funding Amount$56M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries A
Top InvestorsCatalio Capital Management, Bruker, Alexandria Venture Investments, Exact Ventures

AbsoluteCARE operates patient-centered Ambulatory ICUs that deliver comprehensive primary and preventative care to vulnerable populations. Their model focuses on treating chronically ill members with integrated services that address both medical needs and social determinants of health.

Year Founded2000
FoundersAlan S. Cohn
Funding Amount$252M
Startup SizeMid-Size Team (51-250)
Last Funding StatusPrivate Equity
Top InvestorsKinderhook Industries, Pacific Life, Lexington Partners, CVS Health Ventures

Royal Farms operates a chain of convenience stores across the Mid-Atlantic, providing customers with fuel and fresh, fast food. The company is especially known for its World-Famous Fried Chicken, a signature offering that has become a regional staple.

Year Founded1959
Founders
Funding Amount$1.8M
Startup SizeMajor Organization (1,001-5,000)
Last Funding StatusGrant
Top InvestorsDelaware Department of Transportation

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