Framingham, Massachusetts hosts a varied collection of 47 startups. The local business landscape has a clear focus on the biotechnology and healthcare industries.
Among them is BPGbio, a biopharma company that has secured $480M in funding. Other notable companies include the clinical-stage biotech firm Alzheon and software testing company Applause.
Below is our list of 47 Framingham startups worth keeping an eye on.
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Get the Sheet for $50Bose engineers high-fidelity audio equipment, including speakers, soundbars, and their world-renowned noise-canceling headphones. Their sound solutions are integrated into everything from home entertainment systems to automotive and aviation applications.
| Year Founded | 1964 |
| Founders | Amar Bose |
| Funding Amount | $430.2k |
| Startup Size | Enterprise Organization (5,001+) |
| Last Funding Status | Equity Crowdfunding |
| Top Investors | — |
BPGbio builds an AI-powered platform that combines patient biology with machine learning to accelerate drug discovery. The clinical-stage biopharma company uses this technology to de-risk the development of new therapeutics for complex diseases.
| Year Founded | 2006 |
| Founders | Niven Narain |
| Funding Amount | $480M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Private Equity |
| Top Investors | — |
Outcome Referrals developed an online platform that assesses patients for a range of medical and behavioral health issues. Their solution helps clarify diagnostic problems and connects patients with the right care providers.
| Year Founded | 2012 |
| Founders | Armen Meguerditchian, David R. Kraus |
| Funding Amount | $2M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Undisclosed |
| Top Investors | — |
Applause provides digital quality and testing services through a global community of professionals who test software on real devices. This crowd-sourced model enables businesses to identify bugs and usability issues before they impact actual customers.
| Year Founded | 2007 |
| Founders | Doron Reuveni, Roy Solomon |
| Funding Amount | $115.8M |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Series F |
| Top Investors | Goldman Sachs, Accenture, Credit Suisse, Scale Venture Partners, Edward Lando |
Variantyx develops advanced molecular diagnostic solutions that help clinicians identify genetic disorders. The company's proprietary Genomic Intelligence platform uses whole genome sequencing to provide comprehensive answers from a single test.
| Year Founded | 2014 |
| Founders | Haim Neerman, Tomer Jackman |
| Funding Amount | $136.5M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series D |
| Top Investors | Bosch Ventures, New Era Capital Partners, Kreos Capital, Pitango VC, Peregrine Ventures |
Alzheon develops oral therapies for neurodegenerative conditions, primarily targeting Alzheimer's disease. This clinical-stage biotechnology company aims to slow disease progression through its novel treatment pipeline.
| Year Founded | 2013 |
| Founders | Martin Tolar |
| Funding Amount | $366.2M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series E |
| Top Investors | Ally Bridge Group, National Institute on Aging, Alerce Medical Technology Partners, Scott H. Cohen |
Punchbowl provides a web-based platform for planning parties, complete with customizable digital invitations and greeting cards. Their service simplifies event organization by helping hosts manage guest lists and track RSVPs for any occasion.
| Year Founded | 2007 |
| Founders | Matt Douglas, Sean Conta |
| Funding Amount | $14.8M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Venture Round |
| Top Investors | Intel Capital, Contour Venture Partners, Silicon Valley Bank, SG Credit Partners, Dharmesh Shah |
DetraPel synthesizes and manufactures advanced protective coatings designed to repel liquids and stains. Their PFAS-free formulas provide a safer, more environmentally friendly alternative for both consumer and industrial applications.
| Year Founded | 2013 |
| Founders | David Zamarin |
| Funding Amount | $14M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series A |
| Top Investors | Cerity Partners Ventures, MassChallenge, Material Impact, Fitz Gate Ventures, Boro Capital |
Raven360 builds a sales readiness platform that delivers consistent content, training, and coaching to sales teams. Their software ensures sales professionals are always equipped with the most up-to-date knowledge and materials to effectively engage buyers.
| Year Founded | 2011 |
| Founders | Joe Moriarty, Vasu Ram |
| Funding Amount | $12.5M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series B |
| Top Investors | Allos Ventures, Nauta Capital, Hub Angels Investment Group, MassVentures, ZetrOZ |
Berg uses its proprietary AI platform, Interrogative Biology®, to map diseases and accelerate the development of new medicines. The clinical-stage biotech company is creating a pipeline of novel therapeutics in complex areas like oncology and neurology.
| Year Founded | 2006 |
| Founders | Niven Narain |
| Funding Amount | $200k |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Grant |
| Top Investors | Alliance of Families Fighting Pancreatic Cancer |
37 Additional Framingham Startups Worth Following
Our top 10 picks offer a great snapshot, but they only tell part of the story. The wider scene is a mix of established names and new ventures, with a strong focus on biotech and healthcare. Some are just getting started, while others are already major local employers. Here’s a look at the rest of the companies that make Framingham’s startup scene one to watch.