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Top 47 Framingham Startups to Watch in 2026

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Framingham, Massachusetts hosts a varied collection of 47 startups. The local business landscape has a clear focus on the biotechnology and healthcare industries.

Among them is BPGbio, a biopharma company that has secured $480M in funding. Other notable companies include the clinical-stage biotech firm Alzheon and software testing company Applause.

Below is our list of 47 Framingham startups worth keeping an eye on.

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Bose engineers high-fidelity audio equipment, including speakers, soundbars, and their world-renowned noise-canceling headphones. Their sound solutions are integrated into everything from home entertainment systems to automotive and aviation applications.

Year Founded1964
FoundersAmar Bose
Funding Amount$430.2k
Startup SizeEnterprise Organization (5,001+)
Last Funding StatusEquity Crowdfunding
Top Investors

BPGbio builds an AI-powered platform that combines patient biology with machine learning to accelerate drug discovery. The clinical-stage biopharma company uses this technology to de-risk the development of new therapeutics for complex diseases.

Year Founded2006
FoundersNiven Narain
Funding Amount$480M
Startup SizeMid-Size Team (51-250)
Last Funding StatusPrivate Equity
Top Investors

Outcome Referrals developed an online platform that assesses patients for a range of medical and behavioral health issues. Their solution helps clarify diagnostic problems and connects patients with the right care providers.

Year Founded2012
FoundersArmen Meguerditchian, David R. Kraus
Funding Amount$2M
Startup SizeLean Team (11-50)
Last Funding StatusUndisclosed
Top Investors

Applause provides digital quality and testing services through a global community of professionals who test software on real devices. This crowd-sourced model enables businesses to identify bugs and usability issues before they impact actual customers.

Year Founded2007
FoundersDoron Reuveni, Roy Solomon
Funding Amount$115.8M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries F
Top InvestorsGoldman Sachs, Accenture, Credit Suisse, Scale Venture Partners, Edward Lando

Variantyx develops advanced molecular diagnostic solutions that help clinicians identify genetic disorders. The company's proprietary Genomic Intelligence platform uses whole genome sequencing to provide comprehensive answers from a single test.

Year Founded2014
FoundersHaim Neerman, Tomer Jackman
Funding Amount$136.5M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries D
Top InvestorsBosch Ventures, New Era Capital Partners, Kreos Capital, Pitango VC, Peregrine Ventures

Alzheon develops oral therapies for neurodegenerative conditions, primarily targeting Alzheimer's disease. This clinical-stage biotechnology company aims to slow disease progression through its novel treatment pipeline.

Year Founded2013
FoundersMartin Tolar
Funding Amount$366.2M
Startup SizeLean Team (11-50)
Last Funding StatusSeries E
Top InvestorsAlly Bridge Group, National Institute on Aging, Alerce Medical Technology Partners, Scott H. Cohen

Punchbowl provides a web-based platform for planning parties, complete with customizable digital invitations and greeting cards. Their service simplifies event organization by helping hosts manage guest lists and track RSVPs for any occasion.

Year Founded2007
FoundersMatt Douglas, Sean Conta
Funding Amount$14.8M
Startup SizeLean Team (11-50)
Last Funding StatusVenture Round
Top InvestorsIntel Capital, Contour Venture Partners, Silicon Valley Bank, SG Credit Partners, Dharmesh Shah

DetraPel synthesizes and manufactures advanced protective coatings designed to repel liquids and stains. Their PFAS-free formulas provide a safer, more environmentally friendly alternative for both consumer and industrial applications.

Year Founded2013
FoundersDavid Zamarin
Funding Amount$14M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top InvestorsCerity Partners Ventures, MassChallenge, Material Impact, Fitz Gate Ventures, Boro Capital

Raven360 builds a sales readiness platform that delivers consistent content, training, and coaching to sales teams. Their software ensures sales professionals are always equipped with the most up-to-date knowledge and materials to effectively engage buyers.

Year Founded2011
FoundersJoe Moriarty, Vasu Ram
Funding Amount$12.5M
Startup SizeLean Team (11-50)
Last Funding StatusSeries B
Top InvestorsAllos Ventures, Nauta Capital, Hub Angels Investment Group, MassVentures, ZetrOZ

Berg uses its proprietary AI platform, Interrogative Biology®, to map diseases and accelerate the development of new medicines. The clinical-stage biotech company is creating a pipeline of novel therapeutics in complex areas like oncology and neurology.

Year Founded2006
FoundersNiven Narain
Funding Amount$200k
Startup SizeLarge Team (251-1,000)
Last Funding StatusGrant
Top InvestorsAlliance of Families Fighting Pancreatic Cancer

37 Additional Framingham Startups Worth Following

Our top 10 picks offer a great snapshot, but they only tell part of the story. The wider scene is a mix of established names and new ventures, with a strong focus on biotech and healthcare. Some are just getting started, while others are already major local employers. Here’s a look at the rest of the companies that make Framingham’s startup scene one to watch.

StartupIndustryYear FoundedAmount RaisedLast Funding Round
DTT logo DTTTravel1999$147MDebt Financing
Bluespec logo BluespecDesign2003$22.3MVenture Round
ClubNFT logo ClubNFTMedia2021$3.9MSeed
Framingham Heart Study logo Framingham Heart StudyHealthcare1948$38MGrant
Cannon Capital logo Cannon CapitalFintech2016$27.6MUndisclosed
Olaris logo OlarisBiotech2013Series B
Solace Therapeutics logo Solace TherapeuticsHealthcare1997$36MSeries B
Veloxint logo VeloxintEnterprise2005$6.9MVenture Round
Qura logo QuraHealthcare2015$1MSeries A
Princeton Review logo Princeton ReviewEducation1981$37MPrivate Equity
Kephera Diagnostics logo Kephera DiagnosticsBiotech2017$4.8MGrant
SCIEX logo SCIEXBiotech1970
PLT4M logo PLT4MMedia2013$2MVenture Round
Trilio logo TrilioCloud2013$39MSeries B
T.J.Maxx logo T.J.MaxxFashion1976
Alyce logo AlyceMarketing2015$46.8MSeries B
examPAL logo examPALEducation2015$2.2MVenture Round
Towerwall logo TowerwallEnterprise1993
Cantrip Seltzer logo Cantrip SeltzerAgTech2020$138.2kSeed
WoundForce logo WoundForceBiotech2015$500kSeed
RaveMobileSafety.com logo RaveMobileSafety.comEnterprise2004$46MPrivate Equity
Magnomer logo MagnomerEnvironment2020$50kSeed
Beacon Mobility logo Beacon MobilityMedia1986Private Equity
Dr. Dental logo Dr. DentalHealthcare2004Private Equity
Tommy's Taxi logo Tommy's TaxiLogistics1946$7.9kGrant
ECA logo ECAMedia1987
Anagram Therapeutics logo Anagram TherapeuticsBiotech
BRZ Insurance logo BRZ InsuranceInsurTech2017
HomeGoods logo HomeGoodsRetail2009
getWise (currently in market as wiseHer) logo getWise (currently in market as wiseHer)Marketplace2018
IDC Financial Insights logo IDC Financial InsightsFintech1964
uTest logo uTestMarketplace2007
RadiantNano logo RadiantNanoHardware2020
WeCare 365 logo WeCare 365Healthcare2015
Cumberland Farms logo Cumberland FarmsRetail1938
Bose Corporation logo Bose CorporationHardware1964
Boston Heart Diagnostics logo Boston Heart DiagnosticsBiotech2007$10.3MSeries C

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