Top 100 Massachusetts Startups to Watch in 2026
Massachusetts is a center for deep technology and life sciences startups. Companies like Commonwealth Fusion Systems are tackling clean energy with nearly $3 billion in funding.
The area is also a breeding ground for artificial intelligence companies, from music creation tool Suno to agricultural technology firm Indigo. Below are the top 100 startups defining the state's business landscape.
Below is our list of 100 Massachusetts startups worth keeping an eye on.
Failory's Top 10 Picks
Indigo develops agricultural technologies that help farmers sustainably improve their profitability. They offer a suite of digital tools and microbial seed treatments that support regenerative farming practices and create a marketplace for carbon credits.
| Year Founded | 2014 |
| Founders | David Berry, Geoffrey von Maltzahn, Ignacio Martinez, Noubar Afeyan |
| Funding Amount | $1.4B |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Venture Round |
| Top Investors | Google, Activant Capital, Flagship Pioneering, G Squared, FedEx |
Commonwealth Fusion Systems is developing commercially viable fusion power plants to provide clean, limitless energy. They are pioneering the use of high-temperature superconducting magnets to build smaller, more cost-effective tokamaks, accelerating the path to a carbon-free grid.
| Year Founded | 2017 |
| Founders | Dan Brunner, Martin Greenwald, Robert Mumgaard |
| Funding Amount | $2.9B |
| Startup Size | Major Organization (1,001-5,000) |
| Last Funding Status | Series B |
| Top Investors | Temasek Holdings, Khosla Ventures, HOF Capital, Quiet Capital, Google |
OpenEvidence builds an AI platform that provides medical search and clinical decision support. Their system helps clinicians quickly synthesize medical literature to find evidence-based answers for patient care.
| Year Founded | 2021 |
| Founders | Daniel Nadler, Zachary Ziegler |
| Funding Amount | $317M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series B |
| Top Investors | Sequoia Capital, Coatue, Conviction, Thrive Capital, Kleiner Perkins |
Suno has developed an AI-powered platform that lets anyone create original music from simple text prompts. Their tool generates complete songs, including lyrics and vocals, turning ideas into polished audio tracks in moments.
| Year Founded | 2022 |
| Founders | Georg Kucsko, Keenan Freyberg, Martin Camacho, Mikey Shulman |
| Funding Amount | $375M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series C |
| Top Investors | Menlo Ventures, Lightspeed Venture Partners, Founder Collective, Matrix, Daniel Gross, Scott Belsky |
Creatio has developed a single platform for businesses to automate their CRM and enterprise workflows using no-code tools. This approach allows companies to build and customize their operational processes without writing a single line of code.
| Year Founded | 2014 |
| Founders | Katherine Kostereva |
| Funding Amount | $268M |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Private Equity |
| Top Investors | Sapphire Ventures, StepStone Group, Volition Capital, Horizon Capital, Horizon Capital |
Odyssey Therapeutics creates precision immunomodulators and oncology medicines for patients with cancer and inflammatory diseases. Their discovery platform is building a portfolio of novel therapies designed to address significant unmet medical needs.
| Year Founded | 2021 |
| Founders | David Pompliano, Gary Glick |
| Funding Amount | $700M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series D |
| Top Investors | TPG, General Catalyst, OrbiMed, Lightspeed Venture Partners, Catalio Capital Management |
Liquid AI builds a new class of artificial intelligence systems that are more efficient and adaptable than traditional models. Their core technology, liquid neural networks, enables the creation of general-purpose AI that can function at any scale.
| Year Founded | 2023 |
| Founders | Alexander Amini, Daniela Rus, Mathias Lechner, Ramin Hasani |
| Funding Amount | $293.2M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series A |
| Top Investors | Automattic, Safar Partners, Samsung NEXT, Isai, Bold Capital Partners |
Lila Sciences develops a scientific superintelligence platform that powers autonomous labs. Their technology is designed to accelerate discovery across life sciences, chemistry, and materials science.
| Year Founded | 2023 |
| Founders | Molly Gibson, Noubar Afeyan |
| Funding Amount | $435M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series A |
| Top Investors | Collective Global Management, The Mathers Foundation, General Catalyst, Alumni Ventures, Abu Dhabi Investment Authority |
Ketryx develops an AI-driven compliance platform that automates documentation tasks for regulated product teams. Their software helps companies in sectors like medical devices and life sciences streamline complex workflows and accelerate their time to market.
| Year Founded | 2021 |
| Founders | Erez Kaminski, Jan Pöschko |
| Funding Amount | $57M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series B |
| Top Investors | Lightspeed Venture Partners, Transformation Capital, 53 Stations, E14 Fund, Ubiquity Ventures |
SimpliSafe designs and sells wireless home security systems, including cameras, smart locks, and alarms, that are made for easy self-installation. They provide homeowners with professional-grade security without requiring professional installation or long-term contracts.
| Year Founded | 2006 |
| Founders | Chad Laurans, Eleanor Laurans |
| Funding Amount | $387M |
| Startup Size | Major Organization (1,001-5,000) |
| Last Funding Status | Debt Financing |
| Top Investors | Alumni Ventures, Sequoia Capital, HPS Investment Partners, Capital One, Eastern Bank |
90 Additional Massachusetts Startups Worth Following
The top 10 are just a small slice of what’s happening across Massachusetts right now. Founders are working on big ideas, especially in AI and biotech, and have raised billions of dollars to grow their companies.
Some are early in their journey, while others are scaling fast. Here’s a look at the other startups shaping the Massachusetts ecosystem.
| Startup | Industry | Year Founded | Amount Raised | Last Funding Round |
|---|---|---|---|---|
 Solo.io | Media | 2017 | $171.5M | Series C |
 SmartBear | Cloud | 2009 | $25M | Private Equity |
 MoldCo | Healthcare | 2023 | $11M | Seed |
 Insilico Medicine | AI | 2014 | $624.3M | Series E |
 Bose | Media | 1964 | $430.2k | Equity Crowdfunding |
 Aura | AI | 2017 | $662.7M | Series G |
 TraceLink | Infrastructure | 2009 | $233.9M | Series D |
 Lightelligence | AI | 2017 | $246.4M | Series C |
 Blue Water Autonomy | Manufacturing | 2024 | $64M | Series A |
 PredictAP | AI | 2020 | $13M | Venture Round |
 Sphere | Enterprise | 2022 | $7.8M | Venture Round |
 Starburst | Analytics | 2017 | $414M | Venture Round |
 QuEra Computing | Hardware | 2018 | $247M | Series B |
 Nasuni | Cloud | 2009 | $247M | Venture Round |
 Shields Health Solutions | Biotech | 2012 | $3.5B | Corporate Round |
 Boston Dynamics | AI | 1992 | $37M | Venture Round |
 Fourth Power | Hardware | 2021 | $39M | Series A |
 Folia Health | Healthcare | 2016 | $17.4M | Series A |
 Treeline Biosciences | Biotech | 2021 | $1.1B | Series A |
 Goldcast | Enterprise | 2020 | $38M | Series A |
 HealthEdge | Enterprise | 2004 | $97.8M | Private Equity |
 Buyers Edge Platform | Logistics | 1998 | $425M | Private Equity |
 Kula Bio | AgTech | 2018 | $72.1M | Series A |
 Sovos | Enterprise | 1979 | $118.8M | Private Equity |
 Wasabi Technologies | Cloud | 2015 | $581.6M | Venture Round |
 Nexamp | Energy | 2007 | $2.4B | Debt Financing |
 Goodpath | Healthcare | 2019 | $30.5M | Series A |
 Eleos Health | AI | 2019 | $128M | Series C |
 CloudZero | Cloud | 2016 | $119.1M | Series C |
 AltrixBio | Biotech | 2019 | $6.2M | Series A |
 meQuilibrium | Analytics | 2010 | $33.5M | Venture Round |
 Eden | Energy | 2017 | $18.2M | — |
 Skyhawk Therapeutics | Biotech | 2016 | $181.2M | Venture Round |
 Hue | Retail | 2021 | $4.7M | Seed |
 LinkSquares | AI | 2015 | $161.5M | Series C |
 Pure Lithium | Hardware | 2020 | $30.3M | Grant |
 HYCU | Cloud | 2018 | $140.5M | Series B |
 Meditech | Healthcare | 1968 | $26M | Corporate Round |
 ShopMy | Marketing | 2020 | $97M | Series B |
 BrainCo | Biotech | 2015 | $7.6M | Series A |
 LightSpun | AI | 2022 | $13M | Series A |
 Factorial Energy | Hardware | 2021 | $240M | Series D |
 ReversingLabs | Analytics | 2009 | $81M | Series B |
 EGenesis | Biotech | 2014 | $456M | Series D |
 Legit Security | AI | 2021 | $73.5M | Series B |
 Connectbase | Analytics | 2015 | $69.7M | Venture Round |
 Mercy BioAnalytics | Biotech | 2018 | $127.3M | Series B |
 Overjet | AI | 2018 | $130.6M | Series C |
 Ensoma | Biotech | 2019 | $258M | Venture Round |
 Crayon | Analytics | 2014 | $38.1M | Series B |
 Hometap | Fintech | 2017 | $967M | Debt Financing |
 7AI | AI | 2023 | $72M | Seed |
 Strand Therapeutics | Biotech | 2017 | $257.2M | Series B |
 CallMiner | Analytics | 2002 | $196.6M | Venture Round |
 EcoSoul Home | Retail | 2021 | $38.1M | Series B |
 Blues | Cloud | 2018 | $98M | Venture Round |
 Predicta Biosciences | Biotech | 2023 | $28.6M | Series A |
 Elektrofi | Healthcare | 2016 | $154.1M | Series C |
 airSlate | Automation | 2006 | $181.5M | Series B |
 New England Patriots | Sports | 1959 | $720M | Private Equity |
 Biobot Analytics | Analytics | 2017 | $41.4M | Series A |
 WHOOP | Analytics | 2012 | $404.8M | Series F |
 Arkea Bio | Biotech | 2022 | $45.5M | Series A |
 AllRock Bio | Biotech | 2024 | $50M | Series A |
 OneLayer | Fintech | 2021 | $14.7M | Seed |
 Orbital Therapeutics | Healthcare | 2022 | $270M | Series A |
 Inari | AgTech | 2016 | $753M | Series G |
 ConcertAI | Analytics | 2018 | $300M | Series C |
 BitSight | Security | 2011 | $399M | Corporate Round |
 Leal Therapeutics | Healthcare | 2021 | $75M | Series A |
 Emulate | Biotech | 2013 | $271.3M | Series F |
 Eyebot | AI | 2021 | $29.9M | Series A |
 Push Security | Security | 2021 | $49M | Series B |
 G-P/Globalization Partners | Enterprise | 2012 | $350M | Private Equity |
 CYVL | AI | 2020 | $23.2M | Series A |
 Recorded Future | Analytics | 2009 | $79M | Venture Round |
 Scipher Medicine | Healthcare | 2014 | $227M | Series D |
 Interactions | AI | 2004 | $162.8M | Venture Round |
 Nanoramic Laboratories | Manufacturing | 2009 | $130.1M | Venture Round |
 Dewpoint Therapeutics | Biotech | 2018 | $346.1M | Series D |
 Origin | Enterprise | 2018 | $72M | Series B |
 VideaHealth | Biotech | 2018 | $66.5M | Series B |
 Bevi | Food | 2013 | $130.3M | Series D |
 CareAcademy | Education | 2013 | $33.3M | Venture Round |
 Neurable | AI | 2015 | $22.8M | Series A |
 Tive | Enterprise | 2015 | $121.9M | Series C |
 Onapsis | Cloud | 2009 | $115.6M | Series D |
 New Balance | Fashion | 1906 | $80k | Grant |
 Opmed.ai | Enterprise | 2020 | $15M | Series A |
 Form Energy | Hardware | 2017 | $1.6B | Debt Financing |
