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Massachusetts is a center for deep technology and life sciences startups. Companies like Commonwealth Fusion Systems are tackling clean energy with nearly $3 billion in funding.
The area is also a breeding ground for artificial intelligence companies, from music creation tool Suno to agricultural technology firm Indigo. Below are the top 100 startups defining the state's business landscape.
Below is our list of 100 Massachusetts startups worth keeping an eye on.
Everything you need to raise funding for your startup, including 3,500+ investors, 7 tools, 18 templates and 3 learning resources.
Buy It For $97 $297 →Information about the industries, countries, and cities they generally invest in.
Get the Sheet for $50Information about their valuation, HQ's location, founded year, name of founders, funding amount and number of employees.
Get the Sheet for $50List of startup investors in the BioTech, Health, and Medicine industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50List of 250 startup investors in the AI and Machine Learning industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50List of 250 startup investors in the FinTech and Finance industries, along with their Twitter, LinkedIn, and email addresses.
Get the Sheet for $50Indigo develops agricultural technologies that help farmers sustainably improve their profitability. They offer a suite of digital tools and microbial seed treatments that support regenerative farming practices and create a marketplace for carbon credits.
Commonwealth Fusion Systems is developing commercially viable fusion power plants to provide clean, limitless energy. They are pioneering the use of high-temperature superconducting magnets to build smaller, more cost-effective tokamaks, accelerating the path to a carbon-free grid.
OpenEvidence builds an AI platform that provides medical search and clinical decision support. Their system helps clinicians quickly synthesize medical literature to find evidence-based answers for patient care.
Suno has developed an AI-powered platform that lets anyone create original music from simple text prompts. Their tool generates complete songs, including lyrics and vocals, turning ideas into polished audio tracks in moments.
Creatio has developed a single platform for businesses to automate their CRM and enterprise workflows using no-code tools. This approach allows companies to build and customize their operational processes without writing a single line of code.
Odyssey Therapeutics creates precision immunomodulators and oncology medicines for patients with cancer and inflammatory diseases. Their discovery platform is building a portfolio of novel therapies designed to address significant unmet medical needs.
Liquid AI builds a new class of artificial intelligence systems that are more efficient and adaptable than traditional models. Their core technology, liquid neural networks, enables the creation of general-purpose AI that can function at any scale.
Lila Sciences develops a scientific superintelligence platform that powers autonomous labs. Their technology is designed to accelerate discovery across life sciences, chemistry, and materials science.
Ketryx develops an AI-driven compliance platform that automates documentation tasks for regulated product teams. Their software helps companies in sectors like medical devices and life sciences streamline complex workflows and accelerate their time to market.
SimpliSafe designs and sells wireless home security systems, including cameras, smart locks, and alarms, that are made for easy self-installation. They provide homeowners with professional-grade security without requiring professional installation or long-term contracts.
The top 10 are just a small slice of what’s happening across Massachusetts right now. Founders are working on big ideas, especially in AI and biotech, and have raised billions of dollars to grow their companies.
Some are early in their journey, while others are scaling fast. Here’s a look at the other startups shaping the Massachusetts ecosystem.
| Startup | Industry | Year Founded | Amount Raised | Last Funding Round |
|---|---|---|---|---|
| Media | 2017 | $171.5M | Series C | |
| Cloud | 2009 | $25M | Private Equity | |
| Healthcare | 2023 | $11M | Seed | |
| AI | 2014 | $624.3M | Series E | |
| Media | 1964 | $430.2k | Equity Crowdfunding | |
| AI | 2017 | $662.7M | Series G | |
| Infrastructure | 2009 | $233.9M | Series D | |
| AI | 2017 | $246.4M | Series C | |
| Manufacturing | 2024 | $64M | Series A | |
| AI | 2020 | $13M | Venture Round | |
| Enterprise | 2022 | $7.8M | Venture Round | |
| Analytics | 2017 | $414M | Venture Round | |
| Hardware | 2018 | $247M | Series B | |
| Cloud | 2009 | $247M | Venture Round | |
| Biotech | 2012 | $3.5B | Corporate Round | |
| AI | 1992 | $37M | Venture Round | |
| Hardware | 2021 | $39M | Series A | |
| Healthcare | 2016 | $17.4M | Series A | |
| Biotech | 2021 | $1.1B | Series A | |
| Enterprise | 2020 | $38M | Series A | |
| Enterprise | 2004 | $97.8M | Private Equity | |
| Logistics | 1998 | $425M | Private Equity | |
| AgTech | 2018 | $72.1M | Series A | |
| Enterprise | 1979 | $118.8M | Private Equity | |
| Cloud | 2015 | $581.6M | Venture Round | |
| Energy | 2007 | $2.4B | Debt Financing | |
| Healthcare | 2019 | $30.5M | Series A | |
| AI | 2019 | $128M | Series C | |
| Cloud | 2016 | $119.1M | Series C | |
| Biotech | 2019 | $6.2M | Series A | |
| Analytics | 2010 | $33.5M | Venture Round | |
| Energy | 2017 | $18.2M | — | |
| Biotech | 2016 | $181.2M | Venture Round | |
| Retail | 2021 | $4.7M | Seed | |
| AI | 2015 | $161.5M | Series C | |
| Hardware | 2020 | $30.3M | Grant | |
| Cloud | 2018 | $140.5M | Series B | |
| Healthcare | 1968 | $26M | Corporate Round | |
| Marketing | 2020 | $97M | Series B | |
| Biotech | 2015 | $7.6M | Series A | |
| AI | 2022 | $13M | Series A | |
| Hardware | 2021 | $240M | Series D | |
| Analytics | 2009 | $81M | Series B | |
| Biotech | 2014 | $456M | Series D | |
| AI | 2021 | $73.5M | Series B | |
| Analytics | 2015 | $69.7M | Venture Round | |
| Biotech | 2018 | $127.3M | Series B | |
| AI | 2018 | $130.6M | Series C | |
| Biotech | 2019 | $258M | Venture Round | |
| Analytics | 2014 | $38.1M | Series B | |
| Fintech | 2017 | $967M | Debt Financing | |
| AI | 2023 | $72M | Seed | |
| Biotech | 2017 | $257.2M | Series B | |
| Analytics | 2002 | $196.6M | Venture Round | |
| Retail | 2021 | $38.1M | Series B | |
| Cloud | 2018 | $98M | Venture Round | |
| Biotech | 2023 | $28.6M | Series A | |
| Healthcare | 2016 | $154.1M | Series C | |
| Automation | 2006 | $181.5M | Series B | |
| Sports | 1959 | $720M | Private Equity | |
| Analytics | 2017 | $41.4M | Series A | |
| Analytics | 2012 | $404.8M | Series F | |
| Biotech | 2022 | $45.5M | Series A | |
| Biotech | 2024 | $50M | Series A | |
| Fintech | 2021 | $14.7M | Seed | |
| Healthcare | 2022 | $270M | Series A | |
| AgTech | 2016 | $753M | Series G | |
| Analytics | 2018 | $300M | Series C | |
| Security | 2011 | $399M | Corporate Round | |
| Healthcare | 2021 | $75M | Series A | |
| Biotech | 2013 | $271.3M | Series F | |
| AI | 2021 | $29.9M | Series A | |
| Security | 2021 | $49M | Series B | |
| Enterprise | 2012 | $350M | Private Equity | |
| AI | 2020 | $23.2M | Series A | |
| Analytics | 2009 | $79M | Venture Round | |
| Healthcare | 2014 | $227M | Series D | |
| AI | 2004 | $162.8M | Venture Round | |
| Manufacturing | 2009 | $130.1M | Venture Round | |
| Biotech | 2018 | $346.1M | Series D | |
| Enterprise | 2018 | $72M | Series B | |
| Biotech | 2018 | $66.5M | Series B | |
| Food | 2013 | $130.3M | Series D | |
| Education | 2013 | $33.3M | Venture Round | |
| AI | 2015 | $22.8M | Series A | |
| Enterprise | 2015 | $121.9M | Series C | |
| Cloud | 2009 | $115.6M | Series D | |
| Fashion | 1906 | $80k | Grant | |
| Enterprise | 2020 | $15M | Series A | |
| Hardware | 2017 | $1.6B | Debt Financing |
