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Top 27 Pennsylvania Startups to Watch in 2026

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Pennsylvania includes a mix of established companies and fast growing startups. Key hubs for these businesses are located in cities like Pittsburgh, Philadelphia, and Conshohocken.

The state's top companies have attracted major funding, with cloud firm Boomi raising nearly $980M. Newer ventures are also seeing success, such as healthcare AI company Abridge which has secured over $757M.

Below is our list of 27 Pennsylvania startups worth keeping an eye on.

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Boomi develops an intelligent integration platform that connects applications, data, and workflows across an organization. Their cloud-native software is used by thousands of companies to automate processes and create unified digital experiences.

Year Founded2000
FoundersRick Nucci
Funding Amount$979.9M
Startup SizeMajor Organization (1,001-5,000)
Last Funding StatusDebt Financing
Top InvestorsTPG, FirstMark, Sixth Street Specialty Lending, Josh Kopelman, Chris Fralic

DuckDuckGo builds a private search engine that doesn't track user activity or search history. The company is best known for its suite of privacy-first tools, including a web browser with built-in protections against online tracking.

Year Founded2008
FoundersGabriel Weinberg
Funding Amount$182.4M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries D
Top InvestorsHOF Capital, Quiet Capital, Union Square Ventures, Thrive Capital, OMERS Ventures

Skild AI builds software to power general-purpose robots, allowing them to learn and execute complex physical tasks. Their platform is designed to help robots adapt to unstructured environments without extensive pre-programming.

Year Founded2023
FoundersAbhinav Gupta Abhinav Gupta, Deepak Pathak
Funding Amount$435M
Startup SizeLean Team (11-50)
Last Funding StatusSeries B
Top InvestorsMenlo Ventures, General Catalyst, NVIDIA, Lightspeed Venture Partners, Sequoia Capital

ZeroEyes builds an AI-powered gun detection platform that uses computer vision to identify firearms on existing security cameras. The software provides real-time alerts to security personnel and first responders, creating critical situational awareness to reduce gun-related violence.

Year Founded2018
FoundersBilly Hunter, Caleb Jones, Dustin Brooks, Mike Lahiff, Rob Huberty, Sam Alaimo, Tim Sulzer
Funding Amount$107.4M
Startup SizeMid-Size Team (51-250)
Last Funding StatusGrant
Top InvestorsAlumni Ventures, Sorenson Capital, Intel Capital, Alpha Intelligence Capital, BroadLight Capital

David's Bridal specializes in wedding attire, offering a wide selection of gowns and accessories for the entire bridal party. The company also operates a large network of physical stores providing in-person services like professional alterations.

Year Founded1950
FoundersDavid Reisberg, Steve Erlbaum
Funding Amount$70M
Startup SizeEnterprise Organization (5,001+)
Last Funding StatusDebt Financing
Top InvestorsCPP Investments

Proscia develops digital pathology software that helps laboratories and life sciences organizations manage and analyze complex pathology data. Their AI-powered platform is designed to accelerate diagnostics and research to advance the standard of care for diseases like cancer.

Year Founded2014
FoundersColeman Stavish, David West, Nathan Buchbinder
Funding Amount$129.8M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries D
Top InvestorsInsight Partners, Hitachi Ventures, Fusion Fund, Flybridge, Alpha Intelligence Capital

Abridge builds an AI platform that automatically drafts clinical notes from conversations between clinicians and their patients. Their technology is designed to eliminate the heavy administrative burden of documentation, freeing up providers to focus on patient care.

Year Founded2018
FoundersFlorian Metze, Sandeep Konam, Shivdev Rao
Funding Amount$757.5M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries E
Top InvestorsAndreessen Horowitz, Khosla Ventures, Lightspeed Venture Partners, Bessemer Venture Partners, IVP

Tendo builds a software platform that connects patients, clinicians, and caregivers for a more cohesive healthcare experience. Their system provides a secure, unified way for all parties to engage throughout the care journey, leading to better overall outcomes.

Year Founded2020
FoundersDan Goldsmith, Jennifer Goldsmith
Funding Amount$187.6M
Startup SizeMid-Size Team (51-250)
Last Funding StatusVenture Round
Top InvestorsGeneral Catalyst, Lux Capital, Jefferson Health System

Pointsville has developed a platform that allows businesses to create and manage their own digital assets and loyalty programs. Their software aims to simplify the process of launching these initiatives, helping companies drive customer engagement and innovation.

Year Founded2020
FoundersGabor Gurbacs
Funding Amount$10M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top InvestorsChainlink Labs, Tether, Dynamo, Valor Capital Group, Itau Unibanco

AKUVO provides cloud-based collections software designed specifically for banks, credit unions, and fintechs. The platform uses data analytics to help these financial institutions manage portfolio risk and streamline their collection strategies.

Year Founded2019
FoundersJay Mossman
Funding Amount$13M
Startup SizeMid-Size Team (51-250)
Last Funding StatusPrivate Equity
Top InvestorsVista Equity Partners, Curql, VyStar Credit Union, Michigan State University Federal Credit Union, Reseda Group

17 Additional Pennsylvania Startups Worth Following

Those top 10 companies are just a small part of the story in Pennsylvania. Founders across the state are building new things in fields like biotech, healthcare, and robotics.

The next group of companies has raised over $1 billion combined. Here’s a look at the rest of the startups catching our attention this year.

StartupIndustryYear FoundedAmount RaisedLast Funding Round
Niche.com logo Niche.comEducation2002$44.3MSeries C
Interius BioTherapeutics logo Interius BioTherapeuticsBiotech2019$175.9MUndisclosed
HealthVerity logo HealthVerityHealthcare2014$142.2MSeries D
Energage logo EnergageMedia2006$15MVenture Round
Asylon logo AsylonRobotics2015$26.8MSeries B
Carnegie Learning logo Carnegie LearningEducation1997$23.9MGrant
Dispatch Bio logo Dispatch BioBiotech2022$216MSeries A
Naturaz logo NaturazFashion2017$1.5MSeed
CytoAgents logo CytoAgentsBiotech2018$21.5MGrant
Efficient Computer logo Efficient ComputerHardware2022$16MSeed
BlastPoint logo BlastPointAnalytics2016$6.2MSeed
Accion Labs logo Accion LabsData2011$93MSecondary Market
Cornelis Networks logo Cornelis NetworksAI2019$93.3MSeries B
Surface Design Solutions logo Surface Design SolutionsManufacturing$465kGrant
ConnectDER logo ConnectDEREnergy2011$80.3MSeries D
Lyric logo LyricFintech2007$90.9MUndisclosed
Purple Lab logo Purple LabAnalytics2016$43MSeries B

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