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Top 100 Palo Alto Startups to Watch in 2026

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Palo Alto remains a key location for technology development, with a strong concentration in artificial intelligence. The area's leading startups are largely focused on creating new AI products for both enterprise and consumer use.

Among them, travel and expense company Navan has attracted $2.2 billion in funding. AI search engine Glean has also raised a significant amount, securing $768.2 million.

Below is our list of 100 Palo Alto startups worth keeping an eye on.

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Glean offers a generative AI platform that acts as a central search engine for a company's internal knowledge and applications. It provides employees with personalized and contextual answers, helping them find information instantly and work more efficiently.

Year Founded2019
FoundersArvind Jain, Piyush Prahladka, Prafful Goel, Sharvanath Pathak, Tony Gentilcore, TR Vishwanath
Funding Amount$768.2M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries F
Top InvestorsGeneral Catalyst, Wellington Management, Citi, Khosla Ventures, Lightspeed Venture Partners

You.com is building a personalized AI search engine designed to give users more control over their information discovery. The platform integrates a conversational AI chatbot, allowing for natural language queries and customized recommendations.

Year Founded2020
FoundersBryan McCann, Richard Socher
Funding Amount$195M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries C
Top InvestorsNorwest Venture Partners, Alumni Ventures, NVIDIA, Radical Ventures, DuckDuckGo

BitGo provides institutional-grade custody, security, and financial services for digital assets. Their platform offers core infrastructure and security solutions that help investors and businesses manage their cryptocurrency holdings.

Year Founded2013
FoundersBen Davenport, Mike Belshe, Will O'Brien
Funding Amount$171.5M
Startup SizeLarge Team (251-1,000)
Last Funding StatusCorporate Round
Top InvestorsValor Equity Partners, Pantera Capital, Craft Ventures, Founders Fund, Goldman Sachs

Vectara provides a developer platform for building generative AI features into new or existing applications. Their technology is focused on grounding AI-generated answers in a company's own data to help eliminate hallucinations.

Year Founded2022
FoundersAmin Ahmad, Amr Awadallah, Tallat Shafaat
Funding Amount$53.5M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top InvestorsAlumni Ventures, Samsung NEXT, FPV Ventures, Vertex Ventures, Fusion Fund

Navan offers a unified platform that combines corporate cards with travel and expense management. Their software helps companies automate tedious financial tasks and gain better control over their spending.

Year Founded2015
FoundersAriel Cohen
Funding Amount$2.2B
Startup SizeMajor Organization (1,001-5,000)
Last Funding StatusConvertible Note
Top InvestorsAndreessen Horowitz, Lightspeed Venture Partners, Goldman Sachs, Coatue, Group 11

Zania builds autonomous AI agents to help businesses manage their security, risk, and compliance posture. The platform automates complex security operations, allowing teams to maintain continuous adherence to industry standards.

Year Founded2023
FoundersShruti Gupta
Funding Amount$18M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top InvestorsAnthropic, Menlo Ventures, New Enterprise Associates, Palm Drive Capital, George Kurtz

Modular builds a unified platform to accelerate AI development and deployment for developers. The company is known for creating Mojo, a new programming language that blends the usability of Python with the performance of C.

Year Founded2022
FoundersChris Lattner, Tim Davis
Funding Amount$380M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries C
Top InvestorsGeneral Catalyst, US Innovative Technology Fund, SV Angel, DFJ Growth, Greylock

Luma AI builds generative AI technology that transforms text descriptions into high-quality 3D models. Their platform allows creators to generate assets for use in virtual reality, augmented reality, and video games.

Year Founded2021
FoundersAlberto Taiuti, Amit Jain
Funding Amount$157.3M
Startup SizeLean Team (11-50)
Last Funding StatusSeries B
Top InvestorsGeneral Catalyst, Andreessen Horowitz, NVIDIA, South Park Commons, Amazon

PlayAI builds generative AI technology to produce human-sounding voices for natural conversations. Their platform is engineered to capture emotive nuances, making digital interactions feel more authentic and engaging.

Year Founded2022
FoundersHammad Syed, Mahmoud Felfel
Funding Amount$23.7M
Startup SizeLean Team (11-50)
Last Funding StatusSeed
Top Investors500 Global, Y Combinator, Kindred Ventures, Pioneer Fund, Race Capital

EarnIn provides a financial wellness app that gives people access to their wages as they earn them. The service is designed to help users avoid overdraft fees and manage their money without waiting for a traditional payday.

Year Founded2013
FoundersRam Palaniappan
Funding Amount$415.1M
Startup SizeLarge Team (251-1,000)
Last Funding StatusDebt Financing
Top InvestorsAndreessen Horowitz, Cross River Bank, Ribbit Capital, Coatue, Spark Capital

90 Additional Palo Alto Startups Worth Following

Our top ten picks are only the beginning of the story in Palo Alto. Across the city, founders are working on everything from AI to biotech, raising billions of dollars in the process.

Some of these companies are brand new, while others are growing fast. Below is a look at the other startups that are shaping the local scene.

StartupIndustryYear FoundedAmount RaisedLast Funding Round
Fable logo FableMedia2019$36MSeries A
SandboxAQ logo SandboxAQAI2016$975MSeries E
micro1 logo micro1AI2022$41.6MSeries A
Rillet logo RilletFintech2021$108.5MSeries B
Epic logo EpicMedia2013$51.5MSeries D
Topsort logo TopsortMarketing2021$28.5MCorporate Round
Harmonic logo HarmonicAI2023$175MSeries B
Eudia logo EudiaAI2023$105MSeries A
Pangea logo PangeaAI2021$51MSeries B
Pika logo PikaAI2023$135MSeries B
Medable logo MedableHealthcare2015$506.6MSeries D
Brightline logo BrightlineEducation2019$212MSeries C
Salt Security logo Salt SecurityAI2015$271MVenture Round
PsiQuantum logo PsiQuantumHardware2016$2.3BSeries E
Hippocratic AI logo Hippocratic AIAI2023$276MSeries B
Kriya Therapeutics logo Kriya TherapeuticsBiotech2019$921.3MSeries D
Penguin Ai logo Penguin AiAI2024$25MSeries A
Augment Code logo Augment CodeAI2022$252MSeries B
Cyberhaven logo CyberhavenAI2014$236.5MSeries D
Parallel logo ParallelAI2023$30MSeries A
Rembrand logo RembrandMarketing2022$31MSeries A
Safe Superintelligence logo Safe SuperintelligenceAI2024$3BVenture Round
Safe Security logo Safe SecurityAI2012$213MSeries C
TinyFish logo TinyFishAI2024$47MSeries A
ClickHouse logo ClickHouseAnalytics2021$750MSeries C
Veza logo VezaSecurity2020$233MSeries D
Birdeye logo BirdeyeAI2012$93MSeries C
Oscilar logo OscilarSecurity2021$20MSeries A
Vannevar Labs logo Vannevar LabsMobility2019$87MSeries B
Denodo Technologies logo Denodo TechnologiesData1999$336MPrivate Equity
AiDASH logo AiDASHAI2019$91.5MSeries C
Zeni logo ZeniFintech2019$47.5MSeries B
Pathway logo PathwayAI2020$14.5MSeed
Ridge Biotechnologies logo Ridge BiotechnologiesBiotech2024$25MSeed
Prophet Security logo Prophet SecurityAI2023$41MSeries A
NoTraffic logo NoTrafficAI2017$75.7MSeries B
Bioz logo BiozBiotech2013$25.7MVenture Round
Glooko logo GlookoHealthcare2010$301MSeries F
SquareX logo SquareXSecurity2023$26MSeries A
Virtana logo VirtanaAnalytics2008$88MVenture Round
Skylark Labs logo Skylark LabsAI2021$7.5MSeed
Inflection AI logo Inflection AIAI2022$1.5BVenture Round
MapLight Therapeutics logo MapLight TherapeuticsBiotech2018$640.6MSeries D
Genspark logo GensparkAI2023$435MSeries B
Sanas logo SanasAI2020$117.7MSeries B
Machinify logo MachinifyAnalytics2016$12.8MSeries A
Ladder logo LadderFintech2015$194MSeries D
Jerry logo JerryAI2017$242MSeries C
Plume Design logo Plume DesignHardware2015$722.4MVenture Round
Opsera logo OpseraAI2020$51.3MSeries B
ThroughPut logo ThroughPutAnalytics2017$11MSeed
Also logo AlsoMobility2025$305MVenture Round
Biostate AI logo Biostate AIAI2023$16MSeries A
Xage Security logo Xage SecurityCrypto2017$81.2MSeries B
Boba Network logo Boba NetworkCrypto2018$115MPrivate Equity
Fizz logo FizzMedia2020$41.5MSeries B
The Interaction Company of California logo The Interaction Company of CaliforniaAI2024$15MSeed
DataHub logo DataHubAI2021$65MSeries B
Atlas AI logo Atlas AIAgTech2018$8.2MGrant
Juvena Therapeutics logo Juvena TherapeuticsBiotech2017$79.7MVenture Round
Turing logo TuringAI2018$270.2MSeries E
Spike Technologies logo Spike TechnologiesInfrastructure2022$4.2MSeed
Endex logo EndexAI2022$14MVenture Round
ORO Labs logo ORO LabsAI2020$59MVenture Round
Birdie logo BirdieAnalytics2019$9.1MSeed
Chai logo ChaiMedia2021$55MUndisclosed
Kick logo KickFintech2021$12MSeed
Sundial logo SundialAnalytics2021$23MSeries A
HiHello logo HiHelloMedia2018$10MSeries A
Bluedot logo BluedotMobility2021$7MSeed
Owner logo OwnerSaaS2018$182.2MSeries C
Federato logo FederatoAI2020$80MSeries C
Uniphore logo UniphoreAI2008$620.9MSeries E
Myome logo MyomeBiotech2017$23MSeries B
Endor Labs logo Endor LabsSecurity2022$188MSeries B
Dinari logo DinariFintech2021$32.4MSeries A
Docker logo DockerInfrastructure2011$435.9MSeries C
CommerceIQ logo CommerceIQAnalytics2012$195.5MSeries D
Aptos logo AptosCrypto2021$350MVenture Round
Ascend.io logo Ascend.ioAnalytics2015$50MSeries B
Kira logo KiraAI2022$22.5MSeries A
Fourier logo FourierEnergy2022$18.6MSeries A
Voyage AI logo Voyage AIAI2023$20MSeries A
Stellic logo StellicEducation2016$14.1MSeries A
OpusClip logo OpusClipAI2022$50MSeries A
MiSalud logo MiSaludHealthcare2021$13MSeries A
CyCognito logo CyCognitoSecurity2017$153MSeries C
Skyflow logo SkyflowAI2019$97MSeries B
Point logo PointFintech2015$538.7MDebt Financing
Clockwork Systems logo Clockwork SystemsAI2018$41.6MVenture Round

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