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The Founder's Handbook

Top 6 Portland Startups to Watch in 2026

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Portland's startup ecosystem features a diverse mix of companies across several key sectors. This includes fields like biopharmaceuticals, financial technology, and cloud data services.

Leading the pack are companies like Sparrow Pharmaceuticals, which has secured $156.3M for its clinical-stage treatments. Close behind is data management firm Hydrolix with $145M in total funding.

Below is our list of 6 Portland startups worth keeping an eye on.

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Hydrolix offers a streaming data lake platform designed for high-volume log data and real-time analytics. Their technology helps engineering and security teams reduce the cost and complexity of managing massive datasets for observability.

Year Founded2018
FoundersHasan Alayli, Marty Kagan
Funding Amount$145M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries C
Top InvestorsQED Investors, Wing Venture Capital, Oregon Venture Fund, Akamai Technologies, Sozo Ventures

Sparrow Pharmaceuticals develops targeted therapies for disorders of corticosteroid excess, a condition also known as hypercortisolism. The clinical-stage biopharmaceutical company is advancing its lead product candidate, clofutriben, as a potential treatment for patients with this condition.

Year Founded2013
FoundersDavid Katz
Funding Amount$156.3M
Startup SizeFounding Team (1-10)
Last Funding StatusSeries B
Top InvestorsOrbiMed, RA Capital Management, U.S. Venture Partners, RiverVest, Forbion Capital Partners

Sila develops a money API platform that provides banking and payment infrastructure as a service for fintech companies. This allows developers to quickly embed a range of financial features directly into their own applications.

Year Founded2018
FoundersAlex Pentland, Alexander Lipton, Angela Angelovska-Wilson, Isaac Hines, Shamir Karkal
Funding Amount$20.7M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries A
Top InvestorsPlug and Play, Madrona, Oregon Venture Fund, Mucker Capital, Revolution Ventures

Fiveonefour created a platform for development teams to build data-intensive features and solutions. Their tools help companies ship complex data products without having to hire specialized data engineers.

Year Founded2023
FoundersChris Crane, Nicolas Joseph, Tim Delisle
Funding Amount$17M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top InvestorsRidge Ventures, Stage 2 Capital, Dimension Capital, Flybridge, Tokyo Black

Boulder Care runs a digital clinic that provides treatment and long-term support for substance use disorders. Their telehealth platform gives patients access to a dedicated care team and medication-assisted treatment from home.

Year Founded2017
FoundersAmanda Wilson, MJ Darby, Stephanie Strong
Funding Amount$85.2M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries C
Top InvestorsGaingels, BoxGroup, Alumni Ventures, Goodwater Capital, Acumen

Brandlive builds a video platform that helps companies produce TV-like virtual events and webinars. Their software gives brands the tools to create and host elevated online experiences that look and feel like a professional television show.

Year Founded2010
FoundersBen McKinley, Fritz Brumder
Funding Amount$22.5M
Startup SizeMid-Size Team (51-250)
Last Funding StatusVenture Round
Top InvestorsOregon Venture Fund, Portland Seed Fund, Archivist, The R-Group, Oregon Entrepreneurs Network

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