Top 53 Lyon Startups to Watch in 2026
Lyon is home to a growing startup scene with companies across many sectors. The city shows particular strength in financial technology and biotechnology.
Leading the way is treasury management platform Agicap, which has secured $166.7M in funding. Other major players include pet insurance company SanteVet and biotech firm Osivax, with funding of €158.7M and $89.1M respectively.
Below is our list of 53 Lyon startups worth keeping an eye on.
Failory's Top 10 Picks
Osivax develops universal vaccines and immunotherapies designed to protect against a broad range of infectious diseases. Their lead candidate is a broad-spectrum influenza vaccine currently in clinical trials, aiming to provide protection against all flu strains.
| Year Founded | 2017 |
| Founders | Alexandre Levert, Florence Nicolas |
| Funding Amount | $89.1M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Grant |
| Top Investors | Bpifrance, Bill & Melinda Gates Foundation, European Innovation Council, Biomedical Advanced Research and Development Authority (BARDA), Anaxago |
Eden AI builds a single API that aggregates the best AI engines for services like computer vision, translation, and speech recognition. This allows developers to easily access and manage multiple AI models through one unified platform.
| Year Founded | 2020 |
| Founders | Samy Melaine, Taha Zemmouri |
| Funding Amount | $4.5M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Seed |
| Top Investors | Bpifrance, BNP Paribas, Societe Generale, Wendel, Galion.exe |
Agicap builds a treasury management platform that gives businesses a real-time view of their cash flow. The software consolidates financial data to help companies manage invoices, track receivables, and forecast their financial health.
| Year Founded | 2016 |
| Founders | Clement Mauguet, Lucas Bertola, Sebastien Beyet |
| Funding Amount | $166.7M |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Series C |
| Top Investors | Partech, AVP, Kima Ventures, BlackFin Capital Partners, Greenoaks |
Cosmo Tech provides digital twin simulation software that helps C-suite leaders make optimal business decisions. Their platform models complex scenarios to predict the impact of potential choices.
| Year Founded | 2010 |
| Founders | Eric Boix, Hugues de Bantel, Michel Morvan |
| Funding Amount | €32.9M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Venture Round |
| Top Investors | Insight Partners, Crédit Agricole, Cathay Innovation, Accenture Ventures, Inven Capital |
Indy builds an AI-powered accounting software to help freelancers and professionals manage their finances. The platform is designed to automate end-to-end accounting tasks, from bookkeeping to tax filings.
| Year Founded | 2016 |
| Founders | Adrien Plat, Come Fouques, Pablo Larvor, Romain Koenig |
| Funding Amount | €86M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Series C |
| Top Investors | Alven, Singular, BlackFin Capital Partners, IXO Private Equity, Kerala Ventures |
iExec runs a decentralized marketplace for cloud computing resources built on the blockchain. Their platform connects providers looking to monetize their computing power, datasets, and applications with users who need those resources.
| Year Founded | 2016 |
| Founders | Gilles Fedak, Haiwu He |
| Funding Amount | €12M |
| Startup Size | Mid-Size Team (51-250) |
| Last Funding Status | Initial Coin Offering |
| Top Investors | — |
MyFit Solutions builds 3D scanning software that enables brands to offer tailor-made products and precise size recommendations. The technology is designed for e-commerce and retail companies looking to reduce returns and improve the customer fitting experience.
| Year Founded | 2018 |
| Founders | Xavier Deshayes |
| Funding Amount | €2.6M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Seed |
| Top Investors | Bpifrance, Provence Business Angels, Key Ventures, Acer Finance |
NETRIS Pharma develops drugs that target dependence receptors, a novel approach to cancer therapy. The clinical-stage company's lead product, NP137, is a monoclonal antibody being investigated for its effectiveness against advanced solid tumors.
| Year Founded | 2008 |
| Founders | — |
| Funding Amount | €12.3M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Series A |
| Top Investors | European Innovation Council |
Umi builds a business development platform that connects companies with customized growth opportunities. They specialize in using technology to foster professional networking for sales, marketing, and innovation partnerships.
| Year Founded | 2014 |
| Founders | — |
| Funding Amount | €5M |
| Startup Size | Lean Team (11-50) |
| Last Funding Status | Venture Round |
| Top Investors | — |
SanteVet provides specialized health insurance for pets, helping owners manage the costs of veterinary care. The company's policies are built to cover a wide range of medical needs, from accidents and illnesses to preventative treatments.
| Year Founded | 2003 |
| Founders | Hugues Salord, Jérôme Salord |
| Funding Amount | €158.7M |
| Startup Size | Large Team (251-1,000) |
| Last Funding Status | Private Equity |
| Top Investors | Serena, Idinvest Partners, Columna Capital |
43 Additional Lyon Startups Worth Following
The top 10 are just a small slice of the activity buzzing across Lyon. Founders are building new things in biotech and AI, and have raised hundreds of millions of euros to support their work.
Some companies are early in their journey, while others are scaling quickly. Here’s a look at the other startups that make Lyon's scene so strong.
| Startup | Industry | Year Founded | Amount Raised | Last Funding Round |
|---|---|---|---|---|
 ENYO Pharma | Biotech | 2014 | €96.5M | Series C |
 Hackuity | Security | 2018 | €17.2M | Series A |
 DATAGALAXY | Analytics | 2015 | €10.9M | Seed |
 ProovStation | AI | 2017 | €10.4M | Series A |
 Sis ID | Fintech | 2016 | €5.1M | Series A |
 Elyse Energy | Manufacturing | 2020 | €120M | Venture Round |
 Dougs Compta | Fintech | 2014 | €25M | Series A |
 NETRI | Biotech | 2018 | €5M | Series B |
 Riverse | Environment | 2021 | €6.5M | Seed |
 BeeBryte | Energy | 2015 | €15.6M | Series C |
 Susu | Biotech | 2015 | €7.3M | Venture Round |
 Vizcab | Manufacturing | 2015 | €11.1M | Series A |
 ATOBA Energy | Energy | 2024 | €1.4M | Pre-Seed |
 Tenacy | Security | 2021 | €8.5M | Seed |
 Bon Vivant | Biotech | 2021 | €20.5M | — |
 Fluid Topics | Media | 2012 | €15M | Series B |
 Antidot | Data | 1999 | €26.1M | Series B |
 Mablink Bioscience | Biotech | 2018 | €35M | Series A |
 Abraxio | SaaS | 2019 | €2M | Seed |
 Diagnoly | AI | 2020 | €6.4M | Seed |
 CTIBiotech | Biotech | 2009 | €500k | Grant |
 Hoji | Energy | 2024 | €8.5M | Seed |
 Santé Académie | Education | 2020 | €14M | Series A |
 Hupso | Education | 2018 | €7M | Venture Round |
 Scaleflex | SaaS | 2016 | €2.3M | Seed |
 Releaf Paper | Manufacturing | 2022 | €2.6M | Grant |
 Esker | Mobility | 1985 | — | — |
 Finishers | Data | 2021 | €3.3M | Seed |
 Fab'entech | Healthcare | 2009 | €41.2M | Debt Financing |
 Laclarée | Fashion | 2016 | €8M | Seed |
 fxhash | Media | 2021 | €5M | Seed |
 Novadiscovery | AI | 2010 | €7.5M | Series A |
 Previa Medical | AI | 2020 | €2.1M | — |
 Objow | Media | 2018 | €2M | Seed |
 Y-Brush | Hardware | 2017 | €6M | Series A |
 Prello | Real Estate | 2021 | €13M | Seed |
 Lys Therapeutics | Biotech | 2021 | €6.3M | — |
 Mojo | AI | 2017 | €5M | Seed |
 Oé | Logistics | 2015 | €5M | Venture Round |
 Infolegale | Analytics | 2008 | €13.8M | Venture Round |
 Sirius NeoSight | Biotech | 2023 | €4.4M | Seed |
 Wavo | Fintech | 2024 | €3.5M | Seed |
 HawkCell | Biotech | 2018 | €5M | Series A |
