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Top 53 Lyon Startups to Watch in 2026

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Lyon is home to a growing startup scene with companies across many sectors. The city shows particular strength in financial technology and biotechnology.

Leading the way is treasury management platform Agicap, which has secured $166.7M in funding. Other major players include pet insurance company SanteVet and biotech firm Osivax, with funding of €158.7M and $89.1M respectively.

Below is our list of 53 Lyon startups worth keeping an eye on.

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Osivax develops universal vaccines and immunotherapies designed to protect against a broad range of infectious diseases. Their lead candidate is a broad-spectrum influenza vaccine currently in clinical trials, aiming to provide protection against all flu strains.

Year Founded2017
FoundersAlexandre Levert, Florence Nicolas
Funding Amount$89.1M
Startup SizeLean Team (11-50)
Last Funding StatusGrant
Top InvestorsBpifrance, Bill & Melinda Gates Foundation, European Innovation Council, Biomedical Advanced Research and Development Authority (BARDA), Anaxago

Eden AI builds a single API that aggregates the best AI engines for services like computer vision, translation, and speech recognition. This allows developers to easily access and manage multiple AI models through one unified platform.

Year Founded2020
FoundersSamy Melaine, Taha Zemmouri
Funding Amount$4.5M
Startup SizeLean Team (11-50)
Last Funding StatusSeed
Top InvestorsBpifrance, BNP Paribas, Societe Generale, Wendel, Galion.exe

Agicap builds a treasury management platform that gives businesses a real-time view of their cash flow. The software consolidates financial data to help companies manage invoices, track receivables, and forecast their financial health.

Year Founded2016
FoundersClement Mauguet, Lucas Bertola, Sebastien Beyet
Funding Amount$166.7M
Startup SizeLarge Team (251-1,000)
Last Funding StatusSeries C
Top InvestorsPartech, AVP, Kima Ventures, BlackFin Capital Partners, Greenoaks

Cosmo Tech provides digital twin simulation software that helps C-suite leaders make optimal business decisions. Their platform models complex scenarios to predict the impact of potential choices.

Year Founded2010
FoundersEric Boix, Hugues de Bantel, Michel Morvan
Funding Amount€32.9M
Startup SizeMid-Size Team (51-250)
Last Funding StatusVenture Round
Top InvestorsInsight Partners, Crédit Agricole, Cathay Innovation, Accenture Ventures, Inven Capital

Indy builds an AI-powered accounting software to help freelancers and professionals manage their finances. The platform is designed to automate end-to-end accounting tasks, from bookkeeping to tax filings.

Year Founded2016
FoundersAdrien Plat, Come Fouques, Pablo Larvor, Romain Koenig
Funding Amount€86M
Startup SizeMid-Size Team (51-250)
Last Funding StatusSeries C
Top InvestorsAlven, Singular, BlackFin Capital Partners, IXO Private Equity, Kerala Ventures

iExec runs a decentralized marketplace for cloud computing resources built on the blockchain. Their platform connects providers looking to monetize their computing power, datasets, and applications with users who need those resources.

Year Founded2016
FoundersGilles Fedak, Haiwu He
Funding Amount€12M
Startup SizeMid-Size Team (51-250)
Last Funding StatusInitial Coin Offering
Top Investors

MyFit Solutions builds 3D scanning software that enables brands to offer tailor-made products and precise size recommendations. The technology is designed for e-commerce and retail companies looking to reduce returns and improve the customer fitting experience.

Year Founded2018
FoundersXavier Deshayes
Funding Amount€2.6M
Startup SizeLean Team (11-50)
Last Funding StatusSeed
Top InvestorsBpifrance, Provence Business Angels, Key Ventures, Acer Finance

NETRIS Pharma develops drugs that target dependence receptors, a novel approach to cancer therapy. The clinical-stage company's lead product, NP137, is a monoclonal antibody being investigated for its effectiveness against advanced solid tumors.

Year Founded2008
Founders
Funding Amount€12.3M
Startup SizeLean Team (11-50)
Last Funding StatusSeries A
Top InvestorsEuropean Innovation Council

Umi builds a business development platform that connects companies with customized growth opportunities. They specialize in using technology to foster professional networking for sales, marketing, and innovation partnerships.

Year Founded2014
Founders
Funding Amount€5M
Startup SizeLean Team (11-50)
Last Funding StatusVenture Round
Top Investors

SanteVet provides specialized health insurance for pets, helping owners manage the costs of veterinary care. The company's policies are built to cover a wide range of medical needs, from accidents and illnesses to preventative treatments.

Year Founded2003
FoundersHugues Salord, Jérôme Salord
Funding Amount€158.7M
Startup SizeLarge Team (251-1,000)
Last Funding StatusPrivate Equity
Top InvestorsSerena, Idinvest Partners, Columna Capital

43 Additional Lyon Startups Worth Following

The top 10 are just a small slice of the activity buzzing across Lyon. Founders are building new things in biotech and AI, and have raised hundreds of millions of euros to support their work.

Some companies are early in their journey, while others are scaling quickly. Here’s a look at the other startups that make Lyon's scene so strong.

StartupIndustryYear FoundedAmount RaisedLast Funding Round
ENYO Pharma logo ENYO PharmaBiotech2014€96.5MSeries C
Hackuity logo HackuitySecurity2018€17.2MSeries A
DATAGALAXY logo DATAGALAXYAnalytics2015€10.9MSeed
ProovStation logo ProovStationAI2017€10.4MSeries A
Sis ID logo Sis IDFintech2016€5.1MSeries A
Elyse Energy logo Elyse EnergyManufacturing2020€120MVenture Round
Dougs Compta logo Dougs ComptaFintech2014€25MSeries A
NETRI logo NETRIBiotech2018€5MSeries B
Riverse logo RiverseEnvironment2021€6.5MSeed
BeeBryte logo BeeBryteEnergy2015€15.6MSeries C
Susu logo SusuBiotech2015€7.3MVenture Round
Vizcab logo VizcabManufacturing2015€11.1MSeries A
ATOBA Energy logo ATOBA EnergyEnergy2024€1.4MPre-Seed
Tenacy logo TenacySecurity2021€8.5MSeed
Bon Vivant logo Bon VivantBiotech2021€20.5M
Fluid Topics logo Fluid TopicsMedia2012€15MSeries B
Antidot logo AntidotData1999€26.1MSeries B
Mablink Bioscience logo Mablink BioscienceBiotech2018€35MSeries A
Abraxio logo AbraxioSaaS2019€2MSeed
Diagnoly logo DiagnolyAI2020€6.4MSeed
CTIBiotech logo CTIBiotechBiotech2009€500kGrant
Hoji logo HojiEnergy2024€8.5MSeed
Santé Académie logo Santé AcadémieEducation2020€14MSeries A
Hupso logo HupsoEducation2018€7MVenture Round
Scaleflex logo ScaleflexSaaS2016€2.3MSeed
Releaf Paper logo Releaf PaperManufacturing2022€2.6MGrant
Esker logo EskerMobility1985
Finishers logo FinishersData2021€3.3MSeed
Fab'entech logo Fab'entechHealthcare2009€41.2MDebt Financing
Laclarée logo LaclaréeFashion2016€8MSeed
fxhash logo fxhashMedia2021€5MSeed
Novadiscovery logo NovadiscoveryAI2010€7.5MSeries A
Previa Medical logo Previa MedicalAI2020€2.1M
Objow logo ObjowMedia2018€2MSeed
Y-Brush logo Y-BrushHardware2017€6MSeries A
Prello logo PrelloReal Estate2021€13MSeed
Lys Therapeutics logo Lys TherapeuticsBiotech2021€6.3M
Mojo logo MojoAI2017€5MSeed
Oé logo Logistics2015€5MVenture Round
Infolegale logo InfolegaleAnalytics2008€13.8MVenture Round
Sirius NeoSight logo Sirius NeoSightBiotech2023€4.4MSeed
Wavo logo WavoFintech2024€3.5MSeed
HawkCell logo HawkCellBiotech2018€5MSeries A

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